States and Fates of Skin Fibroblasts Revealed Through Chromatin Accessibility

    February 2022 in “ Journal of Investigative Dermatology ”
    Donovan Correa-Gallegos, Hans-Günther Machens, Yuval Rinkevich
    Studysummary The researchers in this study found that neonatal mouse skin fibroblasts show distinct chromatin landscapes directing differentiation into dermal papilla or adipocyte lineages, and such plasticity may inform strategies for enhancing regenerative capacities in adult skin.
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    Research cited in this study 4

    1. Single-Cell Transcriptomic Analysis of Small and Large Wounds Reveals the Distinct Spatial Organization of Regenerative Fibroblasts Experimental Dermatology · 2020
    2. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing Cell stem cell · 2020
    3. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    4. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013