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This study found that newborn hair caffeine content reflects maternal caffeine intake during the third trimester, providing a potential method for assessing fetal caffeine exposure.

This article discusses the potential for topical caffeine as a natural alternative for treating androgenetic alopecia due to its ability to penetrate skin, but it reports no new clinical findings.

This study developed a caffeine-loaded solid lipid nanoparticle gel, observing significant reduction in subcutaneous fat tissue thickness in histological tests compared to an untreated group, suggesting it could effectively treat cellulite as a promising nanocosmeceutical gel.

In this study using ex vivo porcine ear skin, researchers found that standard nail varnish applied gently creates effective follicular closures, preventing penetration of certain substances like fluorescein sodium salt and caffeine into hair follicles, whereas solvent-free varnish and rapid application techniques were less effective.

This study found that optimizing chitosan-tripolyphosphate nanoparticles can enhance the sustained percutaneous delivery of caffeine, with certain conditions affecting stability and release rates.

This review highlights the potential of Coffea arabica as an active ingredient in skincare, noting its bioactive compounds from leaves and beans show promising anticellulite, anti-inflammatory, antioxidant, and anti-aging properties, with unique phenolic concentrations in leaves offering enhanced skin benefits.

Caffeine can damage hearing cells and affect hearing recovery after ear trauma.

This review discusses the potential dermatological benefits of caffeine for hair growth, rosacea, and skin cancer, but notes significant limitations in available research.

The conclusion is that a new method can measure caffeine and drugs in hair, finding caffeine abusers have 70 times more caffeine than normal, with a proposed cut-off value for abuse.

Caffeine in hair might help identify people, but it's not always reliable.

This review discusses recent patents on the cosmetic use of coffee and its by-products, highlighting their potential as promising topical formulation ingredients with skin health benefits.

This study suggests that caffeine may enhance hair growth and be beneficial for cosmetic applications due to its high binding affinity to keratin, but further validation is needed.

This study found that caffeic acid reduced UVB-induced damage and oxidative stress in human dermal papilla cells, suggesting its protective efficacy against such cellular damage.

This study found that a novel shampoo formulation effectively delivers caffeine to hair follicles, with 8–9% of absorbed caffeine reaching the follicles, suggesting it may support hair retention by enhancing antioxidant activity.

This study found that double-fermented green coffee bean extracts displayed strong antioxidant, anti-inflammatory, and dermal papilla cell growth-promoting activities, suggesting potential use in cosmetics for scalp and hair health.

Caffeine may protect hair follicles from stress-related hair loss.

This study found that a topical compounded formulation may improve hair density and general appearance in male patients with androgenetic alopecia after 6 months of use.

Topical caffeine improves hair loss intensity, speed, and shedding, and works better with minoxidil/azelaic acid.

This study measured caffeine content in ethanolic extracts of robusta coffee beans, finding 221.58 mg of caffeine per gram of extract, which aligns with known levels for Coffea canephora.

In this study, women in their 40s with hair loss showed significant improvements in hair properties such as pore density and hair thickness when treated with a caffeine-based scalp ampoule and Microneedle Therapy System, compared to a caffeine-free control.

In this study, a novel liposomal formulation combining caffeine and cafestol significantly enhanced their penetration into human skin layers, with formulation F9 doubling caffeine and greatly increasing cafestol levels in the dermis, suggesting potential for improved topical delivery.

This study found that neither caffeine nor N,N-dimethylglycine treatments were toxic to balding or nonbalding dermal papilla cells and could stimulate calcium influx, indicating treatment responsiveness.

This study found that ex vivo, the skin permeability of caffeine increased with formulations using natural caffeine from coffee extract, particularly when combined with 2.5% Transcutol P, compared to synthetic caffeine formulations.

This chapter explores the evolving cultural and scientific significance of coffee, highlighting how traditional beliefs, brewing innovations, and globalization have shaped its consumption and cultural impact across different societies.

This study suggests that topical caffeine may be a safe and promising treatment for hair loss, but the researchers highlight the need for more large-scale randomized trials to confirm its efficacy.

In this study, researchers developed a multifunctional hydrogel (FVP@CCN) that demonstrated over 90% wound closure in 7 days in diabetic wound models, thanks to its antibacterial, antioxidant, anti-inflammatory, and angiogenesis-promoting properties.

The researchers reported that a newly developed photo-cross-linked hydrogel with multifunctional properties, including antimicrobial and antioxidant effects, significantly improved diabetic wound healing, achieving over 90% wound closure in seven days in vivo.

Vitamin D3-coated nanoparticles effectively deliver caffeine for alopecia treatment with minimal side effects.

In this study, a DMG-Na and caffeine-containing shampoo significantly reduced hair loss and increased hair density in men with male pattern hair loss over 6 months, compared to a placebo, without adverse effects.

In this study, researchers using a UVB-induced mouse model identified the gene COL7A1 as a novel marker for hair luster, finding that minoxidil, caffeine, and biotin effectively restored its expression, indicating potential therapeutic strategies.