Compatibility of Caffeine, Clobetasol Propionate, Dutasteride, Nicotinamide, and Progesterone in TrichoFoam, a Natural Vehicle for Hair Foams

The study assessed the physicochemical and microbiological stabilities of formulations compounded with TrichoFoam™, a ready-to-use foaming vehicle for managing and treating alopecia. The formulations contained varying concentrations of caffeine, clobetasol propionate, dutasteride, nicotinamide, and progesterone. High-performance liquid chromatography (HPLC) analyses and Antimicrobial Effectiveness Testing were conducted. The results showed that most formulations had a beyond-use date of at least 90-180 days, except for clobetasol propionate (14 days) and dutasteride 0.25% (30 days). The study concluded that TrichoFoam™ can be an excellent alternative for personalized alopecia treatment due to the stability of the active pharmaceutical ingredients from different pharmacological classes.