Compatibility of Cetirizine Hydrochloride, Dutasteride, Hydrocortisone Acetate, Nicotinamide, Progesterone, and Pyridoxine Hydrochloride in TrichoSol, A Natural Vehicle for Hair Solutions

    October 2024 in “ PubMed ”
    Hudson Polonini, Sarah Taylor, C Silva
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    TLDR TrichoSolTM is safe for hair loss treatments with specific ingredient stability for up to 180 days.
    This study evaluated the chemical and microbiological stability of various active pharmaceutical ingredients in TrichoSolTM, a vehicle used in hair solutions for alopecia. Using HPLC analyses and Antimicrobial Effectiveness Testing, the researchers determined the beyond-use dates (BUDs) for different concentrations of the ingredients. The BUDs were found to be 180 days for cetirizine hydrochloride (0.5%-2.0%), dutasteride (0.1%), hydrocortisone acetate (0.5%), nicotinamide (0.25%-0.50%), progesterone (1.0%), and pyridoxine hydrochloride (0.25%-5.0%). Shorter BUDs were observed for higher concentrations: 150 days for hydrocortisone acetate (1.0%), 120 days for dutasteride (0.25%), and 90 days for progesterone (2.5%). These findings support the safe use of TrichoSolTM in compounding pharmacies for hair loss treatments.
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