Compatibility of Cetirizine Hydrochloride, Dutasteride, Hydrocortisone Acetate, Nicotinamide, Progesterone, and Pyridoxine Hydrochloride in TrichoSol, A Natural Vehicle for Hair Solutions

The study evaluates the compatibility of several active pharmaceutical ingredients—cetirizine hydrochloride, dutasteride, hydrocortisone acetate, nicotinamide, progesterone, and pyridoxine hydrochloride—in TrichoSolTM, a natural vehicle used for hair solutions in treating alopecia. Using HPLC analyses and Antimicrobial Effectiveness Testing, the research determined the physical-chemical and microbiological stabilities of these compounds. The beyond-use dates (BUDs) for these ingredients in TrichoSolTM were established as follows: 180 days for cetirizine hydrochloride (0.5%-2.0%), dutasteride (0.1%), hydrocortisone acetate (0.5%), nicotinamide (0.25%-0.50%), progesterone (1.0%), and pyridoxine hydrochloride (0.25%-5.0%). Shorter BUDs were noted for hydrocortisone acetate (1.0%) at 150 days, dutasteride (0.25%) at 120 days, and progesterone (2.5%) at 90 days. This information is crucial for ensuring the safe and effective use of these compounds in hair loss treatments.