Interest of a Cinchona Succirubra Extract and Its Association with Caffeine in Hair Loss

The document presents a study on the effects of a Cinchona succirubra extract and its combination with Caffeine on hair loss. The extract targets the Wnt/β-catenin pathway, which is involved in hair growth regulation, and stimulates the expression of Syndecan-1, a protein involved in hair anchoring. The study involved 53 subjects with acute telogen effluvium who applied a serum containing both ingredients thrice weekly for 16 weeks. Results showed significant improvements in hair density, anagen to telogen ratio, hair count, thickness, volume, and mass. The extract significantly inhibited DKK1 production (a protein that inhibits hair growth) and stimulated Syndecan-1 production in association with Caffeine. Subjects also reported a significant decrease in hair loss after shampooing, brushing, and found their hair stronger. The study concludes that the Cinchona succirubra extract, especially in combination with Caffeine, shows promise in treating hair loss.