Interest of a Cinchona Succirubra Extract and Its Association with Caffeine in Hair Loss
May 2023
Cinchona succirubra extract caffeine Wnt/β-catenin pathway Syndecan-1 telogen effluvium DKK1 anagen/telogen ratio anagen hair telogen hair Cinchona extract coffee extract hair growth pathway hair anchoring protein acute hair shedding hair growth inhibitor hair growth/resting phase active growth hair resting phase hair
TLDR Cinchona succirubra extract with caffeine reduces hair loss and strengthens hair.
The document presents a study on the effects of a Cinchona succirubra extract and its combination with caffeine on hair loss. The extract targets the Wnt/β-catenin pathway, which is involved in hair growth regulation, and stimulates the expression of Syndecan-1, a protein involved in hair anchoring. The study involved 53 subjects with acute telogen effluvium who applied a serum containing both ingredients three times a week for 16 weeks. Results showed that the extract significantly inhibited DKK1 production (a protein that inhibits hair growth) and stimulated Syndecan-1 production. There was a significant improvement in the anagen/telogen ratio (active growth/resting phase of hair follicles) from 4 weeks of application, with an increase in anagen hair and a reduction of telogen hair. Subjects also reported a significant decrease in hair loss after shampooing, brushing, and found their hair stronger. The study concludes that the Cinchona succirubra extract, especially in combination with caffeine, effectively regulates the hair cycle and strengthens hair anchoring, thus reducing hair loss.
