A Review: Pharmacological Activities of Quinoline Alkaloids of Cinchona Species

    September 2022 in “ Biointerface Research in Applied Chemistry ”
    Hariyanti Hariyanti, Rachmat Mauludin, Yeyet C. Sumirtapura, Neng Fisheri Kurniati
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    Studysummary This review examines the pharmacological potential of quinoline alkaloids from Cinchona bark for developing new drugs and cosmetics but reports no new findings. Our plain-language summary of this paper — not a Tressless recommendation.
    The review discusses the pharmacological activities of quinoline alkaloids from Cinchona species, traditionally used for malaria treatment, and highlights their potential beyond antimalarial effects. These alkaloids, including quinine, cinchonidine, cinchonine, and quinidine, show promise as anticancer agents, antioxidants, antidiabetics, antifungals, and hair growth stimulants, particularly through the activation of the Wnt/b-catenin pathway. The review emphasizes the importance of these compounds in modern medicine and cosmetics, suggesting their potential for broader therapeutic applications and the need for effective delivery systems to enhance their benefits.
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