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This study found that antisense oligonucleotides can significantly reduce androgen receptor expression in cultured human sebocytes and may offer new therapeutic possibilities for androgen-associated skin diseases.

This review highlights the crucial role of vitamin D signaling in epidermal stem cells during skin wound healing, emphasizing its distinct functions from calcium metabolism and its importance in genomic regulation mediated by the vitamin D receptor.

In this study, researchers found that the absence of type I or type II keratins in mice leads to severe skin barrier defects, highlighting keratins' crucial role in epidermal structure and function.

This study indicates that activating K+ channels in dermal papilla cells alone may not promote hair growth, despite some openers being effective on certain channels.

This review discusses the role of the unliganded vitamin D receptor in hair follicle cycling and tumor formation in mice and reports no new experimental findings.

This study found that exosomes and secretome derived from rat hair follicle stem cells show promising potential for wound healing and tissue repair, demonstrating significant wound closure and suggesting their broader applicability in regenerative medicine.

This study suggests that trichohyalin is modified by peptidyl-arginine deiminase before being cross-linked by TGase 3, allowing the formation of rigid structures in hair follicle cells.

This study found that interleukin-1 directly induces the expression of keratin 6 in keratinocytes, which is a marker of activation and involved in inflammatory skin responses.

This ex vivo study reported that melatonin significantly improved certain aging biomarkers in aged human skin, including reduced mTORC1 activity, increased fibrillin-1, and enhanced collagen and elastic fiber organization, though other key biomarkers remained unchanged.

The authors conclude that optimizing hair shaft production and appearance may best be achieved by integrating biological, chemical, and physical intervention strategies.

In this study, ginger peel polysaccharides modified with zinc reduced inflammation in zebrafish by altering cytokine expression, suggesting potential for treating chronic inflammation-related diseases.

This study reports that topical fish oil treatment in GsdmA3 Dfl/+ mice increased cellular proliferation and macrophages but did not affect COX-2 expression related to psoriasis-like skin changes.

In this study, NMN was found to reverse hair follicle atrophy, thinning, and sparsity in mice induced by DHT, and significantly decreased DHT-induced inflammation and oxidative stress in cultured human dermal papilla cells, enhancing hair growth-related markers.

This study observed unexpected heterogeneity among pigment cells in human scalp hair follicles, identifying immature melanocyte populations outside traditional pigment production zones, raising questions about their potential roles beyond melanin synthesis.

In this study, researchers identified that keloid fibroblasts respond to neurotransmitters from catecholaminergic nerves by producing bone matrix proteins, mediated by β1-adrenergic receptor activation, leading to fibro-osseous reprogramming; blocking this signaling in a rodent model prevented the development of keloid-like pathology.

This study found that 3-hydroxypropionic acid improved the function of hair follicle cells under oxidative stress, suggesting potential as a treatment for stress-related hair loss.

This article compares two rare genetic diseases, vitamin D-dependent rickets type 1 and type 2, focusing on their similar presentations of hypocalcemia and rickets in infancy, but reports no new clinical results.

This study found that peripheral clock genes, particularly BMAL1 and Period1, modulate human hair follicle cycling, suggesting their potential as therapeutic targets for affecting hair growth.

This study found that alkylation of kerateine cysteine residues created a cell-compatible method for controlling hydrogel erosion rates and therapeutic agent release in keratin-based systems.

This study highlights the complex role of the vitamin D receptor in skin processes, where its disruption, along with calcium and co-regulator imbalances, could contribute to skin cancer development by altering skin differentiation and hair follicle cycling.

This study observed that in vitro exposure to dihydrotestosterone worsened COVID-19 spike protein-induced endothelial injury, while spironolactone showed potential in reducing this effect, suggesting a rationale for further evaluation in treating COVID-19.

This study observed that VEGF165 increases proliferation and migration but alters adhesion properties of cultured human hair follicle cells, indicating a potential role for VEGF/VEGFR-2 in hair follicle regulation beyond angiogenesis.

This study found that calbindin-D9k knockout mice on a maternal vitamin D-deficient and low-calcium diet developed transient alopecia, but a high-vitamin D and calcium diet in mothers reduced this effect.

Certain tyrosine kinases may regulate hair growth and could help develop hair loss treatments.

This review explores the potential of self-amplifying RNA technology for protein replacement therapy in various health disorders but reports no new experimental results, indicating challenges remain for clinical approval.

This study developed a genetic toolbox to engineer Cutibacterium acnes for dermal applications, successfully creating a strain that secretes antioxidants to reduce oxidative stress in a UV stress model.

In this study, induction nab-paclitaxel plus cisplatin, combined with nimotuzumab and IMRT, followed by S-1 adjuvant chemotherapy, showed excellent survival benefits with tolerable toxicities for stage N3 nasopharyngeal carcinoma patients.

In this study, umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles were found to improve wound healing in type 2 diabetic mice by inhibiting macrophage pyroptosis and reducing oxidative stress levels.

This article discusses the role of human scalp hair follicles in neurohormone production and their model potential for studying neuroendocrine signaling, reporting no experimental results.

This study found that the vitamin D receptor plays a crucial role in hair follicle development in cashmere goats by regulating signaling pathways in dermal papilla cells.