Effect of Potassium Channel Openers on Potassium Channels in Cultured Human Dermal Papilla Cells

August 1997 in “ PubMed ”

Hiroyasu Hamaoka, Kazuo Minakuchi, Hirokazu Miyoshi, S. Arase, C H Chen, Yutaka Nakaya

minoxidil sulfate pinacidil K+ channel openers cultured human dermal papilla cells Ca(2+)-activated K+ channel KCa channel KATP channels sodium nitroprusside dibutyryl cGMP cGMP-mediated activation nitrovasodilators minoxidil Rogaine

TLDR Increased K+ permeability alone may not promote hair growth.

The study investigated the effects of K+ channel openers, specifically minoxidil sulfate and pinacidil, on K+ channels in cultured human dermal papilla cells. Using the patch clamp technique, researchers found that the Ca(2+)-activated K+ (KCa) channel was dominant, while KATP channels were not observed. Minoxidil and pinacidil did not activate KATP or KCa channels. However, the KCa channel was activated by sodium nitroprusside and dibutyryl cGMP, indicating cGMP-mediated activation. The study concluded that increased K+ permeability in dermal papilla cells alone might not be sufficient to promote hair growth, as nitrovasodilators, which activate KCa channels, do not affect hair growth.

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Related Research

2 / 2 results

research Effect of Potassium Channel Openers on Potassium Channels in Cultured Human Dermal Papilla Cells

20 citations , August 1997 in “PubMed”

Increased K+ permeability alone may not promote hair growth.

research Effect of Minoxidil Sulfate and Pinacidil on Single Potassium Channel Current in Cultured Human Outer Root Sheath Cells and Dermal Papilla Cells

16 citations , July 1994 in “Journal of Dermatological Science”

Minoxidil sulfate and pinacidil may promote hair growth through increased blood flow, not by activating potassium channels.