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Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells

research Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells

1 citations , August 2023 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics”

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

research Effect of Potassium Channel Openers on Potassium Channels in Cultured Human Dermal Papilla Cells

20 citations , August 1997 in “PubMed”

Increased K+ permeability alone may not promote hair growth.

research Androgenetic Alopecia

5 citations , May 1994 in “Facial plastic surgery clinics of North America”

Minoxidil was promising for treating male and female pattern baldness in 1994, but more research on genetics and other treatments was needed.

research Output Displacement Error Evaluation of Multi-Degree-of-Freedom Mechanism Under Arbitrary Load Directions: Proposal of Evaluation Method and Stiffening of 3-Degree-of-Freedom Spatial Parallel Mechanism (Mechanical Dynamics, Measurement, Automatic Control)

January 2005 in “日本機械学會論文集. C編”

Minoxidil sulfate and pinacidil promote hair growth likely by increasing blood flow, not by activating K channels.

research Enhanced In Vitro Hair Growth at the Air-Liquid Interface: Minoxidil Preserves the Root Sheath in Cultured Whisker Follicles

12 citations , July 1993 in “In Vitro Cellular & Developmental Biology - Animal”

Minoxidil enhances hair growth and preserves the root sheath in cultured follicles.

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community Sustaining minoxidil dependent hairs?

in Research/Science 9 upvotes 1 year ago

Minoxidil-dependent hairs fall out if minoxidil is stopped. New treatments like GT20029, FOL055, or TDM105795 might help sustain these hairs.

community REVOLUTION in AUGUST: New possibilities according to Dr. Muñoz (pinacidil, cromakalim, diazoxide and nicorandil)

in Technology 13 upvotes 5 months ago

Dr. Muñoz's discovery suggests that targeting potassium channels in fibroblasts could reactivate hair growth, offering new treatment possibilities for alopecia. Potential strategies include using minoxidil, diazoxide, and other potassium channel openers, as well as bioelectric devices and direct growth factor applications.

community P-1075: a BETTER version of Minoxidil

in Research/Science 4 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community Creatine is the opposite of minoxidil !

in Research/Science 323 upvotes 4 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community 28M experiencing thinning - first timer here, please help

cgem753 in Treatments 370 upvotes 3 months ago

A 28-year-old male experiencing hair thinning is considering minoxidil and finasteride. Minoxidil helps regrow hair, while finasteride prevents further loss; both are usually lifelong treatments.