The Role of ATP-Sensitive Inward Rectifier Potassium Channels in the Regulation of Reactive Oxygen Species in the Western Honey Bee, Apis Mellifera L.
June 2022
TLDR Activating certain potassium channels in honey bees can lower antioxidant levels and reduce death rates during heavy mite infestations, potentially aiding their immune response.
This 2019 thesis study investigated the role of ATP-sensitive inward rectifier potassium channels (KATP channels) in the regulation of reactive oxygen species (ROS) in honey bees, and their potential impact on bee survival during viral infections. The study found that pinacidil, a KATP channel activator, significantly reduced antioxidant levels in bees during chemically-induced ROS, suggesting that KATP channels help regulate ROS levels. Additionally, the study observed reduced mortality in bees from colonies with heavy mite infestations, supporting the idea that ROS plays a role in immune health. While further research is needed to fully understand the relationship between KATP channels, ROS, and antiviral immunity, these findings contribute to the understanding of how honey bees regulate their antiviral immune response.
