Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

    August 2023 in “ International Journal of Molecular Sciences ”
    Cristina Casalou, Jay M. Mayatra, Desmond J. Tobin
    Studysummary This study observed unexpected heterogeneity among pigment cells in human scalp hair follicles, identifying immature melanocyte populations outside traditional pigment production zones, raising questions about their potential roles beyond melanin synthesis.
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    Research cited in this study 13

    1. Loss of Epidermal Melanin Unit Integrity in Human Skin During Melanoma Genesis Frontiers in oncology · 2022
    2. The biology of human hair greying Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2020
    3. From Neural Crest Cells to Melanocytes: Cellular Plasticity During Development and Beyond Cellular and Molecular Life Sciences · 2019
    4. Identification of Hair Shaft Progenitors That Create a Niche for Hair Pigmentation Genes & development · 2017
    5. Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress International Journal of Cosmetic Science · 2013
    6. Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile Involving Catalase ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    7. The Cell Biology of Human Hair Follicle Pigmentation Pigment cell & melanoma research · 2010
    8. Aging of the Hair Follicle Pigmentation System International journal of trichology · 2009
    9. Changes in Different Melanocyte Populations During Hair Follicle Involution (Catagen) ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    10. Melanocyte Stem Cell Maintenance and Hair Graying Cell · 2005
    11. Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    12. Principles of Hair Cycle Control The Journal of Dermatology · 1998
    13. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993

    Related research 5

    1. Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity International Journal of Molecular Sciences · 2023
    2. Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity 2023
    3. Direct Conversion of Mouse and Human Fibroblasts to Functional Melanocytes by Defined Factors Nature Communications · 2014
    4. An Approach to Disorders of Pigmentation British Small Animal Veterinary Association eBooks · 2012
    5. Human Skin Color: Origin, Variation, and Significance Journal of Human Evolution/Journal of human evolution · 1985