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GlossaryTyrosinase-Related Protein 2 (DCT)

enzyme crucial for melanin production in hair and skin

Tyrosinase-Related Protein 2 (TRP-2), also known as Dopachrome Tautomerase (DCT), is an enzyme involved in the production of melanin, the pigment responsible for hair, skin, and eye color. It plays a crucial role in the melanin biosynthesis pathway by converting dopachrome into dihydroxyindole-2-carboxylic acid (DHICA), which helps determine the type and amount of melanin produced. This protein is significant in studies related to pigmentation disorders and melanoma.

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research Wnt/β-Catenin Signaling Pathway Activates Melanocyte Stem Cells In Vitro and In Vivo

45 citations, April 2016 in “Journal of Dermatological Science”

The Wnt/β-catenin pathway can activate melanocyte stem cells and may help regenerate hair follicles.

research Sox2 in the Dermal Papilla Regulates Hair Follicle Pigmentation

9 citations, July 2022 in “Cell reports”

Sox2 controls hair color by affecting pigment production in hair follicles.

research Epicardial Fat Thickness in Children with Classic Congenital Adrenal Hyperplasia

9 citations, February 2019 in “Journal of Clinical Research in Pediatric Endocrinology”

Children with classic congenital adrenal hyperplasia have thicker heart fat and are at higher risk for heart problems and early atherosclerosis.

research Differentiation of CD34+ Human Hair Follicle Stem Cells into Functional Melanocytes

1 citations, December 2018 in “IOP conference series. Materials science and engineering”

CD34+ hair follicle stem cells can become melanin-producing cells for treating skin conditions.

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

August 2023 in “International Journal of Molecular Sciences”

The human scalp hair bulb contains different types of melanocytes with varying abilities to produce melanin.

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