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GlossaryTyrosinase-Related Protein 2 (Dopachrome Tautomerase)

enzyme crucial for melanin production in hair and skin

Tyrosinase-Related Protein 2 (TRP-2), also known as Dopachrome Tautomerase (DCT), is an enzyme involved in the production of melanin, the pigment responsible for hair, skin, and eye color. It plays a crucial role in the melanin biosynthesis pathway by converting dopachrome into dihydroxyindole-2-carboxylic acid (DHICA), which helps determine the type and amount of melanin produced. This protein is significant in studies related to pigmentation disorders and melanoma.

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research Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle

161 citations , June 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair stops producing melanin as it transitions from the growth phase to the resting phase.

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

August 2023 in “International Journal of Molecular Sciences”

The human scalp hair bulb contains different types of melanocytes with varying abilities to produce melanin.

research Targeted Knockout of Beta-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects

3 citations , October 2020 in “Journal of Investigative Dermatology”

Removing β-catenin in certain stem cells causes hair whitening and pigmentation issues.

research Exploring the Role of Melanocyte Subpopulations in Vitiligo

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

A specific group of early-stage melanocytes is reduced in vitiligo-affected skin, which may explain treatment resistance.

research Differentiation of CD34+ Human Hair Follicle Stem Cells into Functional Melanocytes

1 citations , December 2018 in “IOP conference series. Materials science and engineering”

CD34+ hair follicle stem cells can become melanin-producing cells for treating skin conditions.

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