In Vivo Response of GsdmA3Dfl/+ Mice to Topically Applied Fish Oil – Effects on Cellular Markers and Macrophages

June 2016 in “ FEBS open bio ”

Mohd Hanif Zulfakar, Rebecca Porter, Charles M. Heard

fish oil GsdmA3^Dfl/+ epidermal thickness cellular proliferation Ki67 macrophage MAC-1 COX-2 betamethasone dipropionate psoriasis eczema

TLDR Fish oil increased cell growth and macrophages in the skin but didn't affect COX-2 expression.

The study investigated the effects of topically applied fish oil on GsdmA3^Dfl/+ mice, which exhibit psoriasis-like symptoms. Fish oil treatment increased epidermal thickness, cellular proliferation (Ki67), and macrophage presence (MAC-1), but did not affect COX-2 expression. Betamethasone dipropionate reduced epidermal thickness and cellular proliferation, while the combined treatment showed no significant difference from the control. The findings suggested that fish oil increases cellular proliferation and macrophages in the epidermis, but COX-2 is not involved in these changes, highlighting challenges in developing fish oil-based topical treatments for conditions like psoriasis and eczema.

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Research cited in this study

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research In Vivo Response of GsdmA3Dfl/+ Mice to Topically Applied Anti-Psoriatic Agents: Effects on Epidermal Thickness, as Determined by Optical Coherence Tomography and H&E Staining

15 citations, February 2011 in “Experimental Dermatology”

Betamethasone dipropionate reduced skin thickness, fish oil increased it, and combined treatment had no significant effect.

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community 5 month results on natural protocol, i made a post after 3 mont of treatment wich you can find in my profile. I used different massages(detumescence therapy, wooden brush, tom hagerty exercises)vitamins(d3,fish oil, biotin,msm, magnesium) drank green tea and ate pumpkin seeds( reduces dht)

in Is this regrowth? 146 upvotes 1 year ago

The user "Zealousideal-Pack340" shared their 5-month results on a natural hair loss treatment protocol, which included massages, vitamins, green tea, and pumpkin seeds. Some users suggested using medications like finasteride and minoxidil for better results, while others criticized the effectiveness of natural remedies. Overall, there was no clear consensus on the progress of the user's hair regrowth.

community If the main mechanism of microneedling is an increase in bloodflow to the scalp, shouldn't we be pursuing other actions which increase bloodflow? Sauna, cold showers, high dosage fish oil, hard cardio, heme-iron(red meats), HAND STANDS, foods high in NO (arugula), ginger, increased water consumption

in Question 17 upvotes 5 years ago

Microneedling stimulates hair growth through stem cell activation during wound healing, not just increased blood flow. Other methods like showers or supplements don't replicate this effect.

community Taking this supplements seem to have significantly reduced my hair fall. Will it help others too?

in Treatment 10 upvotes 3 years ago

Taking curcumin, omega-3 fish oil, vitamin D, and theaflavin supplements significantly reduced hair fall. The user suggests others try these supplements and report their results.

community AMA: Fin for almost 18 months (update/pics/regime included)

in Finasteride 8 upvotes 7 years ago

User discusses using finasteride, ketoconazole, fish oil, nettle root, saw palmetto, emu oil, and plans to start minoxidil for hair loss. They report maintaining hair with minor side effects like slightly lower libido and watery semen.

community Finally Scalp Folliculitis-Free after 2 Decades of Suffering

in Treatment 61 upvotes 1 month ago

A 37-year-old male resolved scalp folliculitis by adopting a low-histamine diet and taking Vitamin A, Zinc, and Fish Oil, leading to better skin health and thicker hair. He warns about the potential toxicity of excessive Vitamin A intake.

community 3.5 months on fin/min progress

in Progress Pictures 1646 upvotes 2 months ago

A 22-year-old male has been using oral finasteride (1.2mg) and oral minoxidil (2.5mg) daily for 3.5 months, along with vitamin D, fish oil, iron, and biotin, and reports significant hair growth without side effects. The user plans to continue the treatment and is considering cutting hair to assess progress more accurately.

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research Development of Pigmented Reconstructed Human Epidermis Model Containing Human Melanoblasts from Keratinocyte Culture

April 2019 in “Journal of Investigative Dermatology”

The created skin model with melanoblasts improves the study of skin color and offers an alternative to animal testing.