Preparation and Characterization of Ginger Peel Polysaccharide–Zn (II) Complexes and Evaluation of Anti-Inflammatory Activity

The study investigated the enhancement of ginger peel polysaccharides' (GPs) bioactivity through zinc modification, resulting in GP–Zn (II) complexes primarily composed of glucose and galactose. These complexes, with a molecular weight of 4.90 × 10^5 Da and 21.17 mg/g Zn content, showed reduced crystallinity and asymmetry. In zebrafish, these complexes effectively reduced CuSO4-induced inflammation by modulating cytokine expression, decreasing pro-inflammatory and increasing anti-inflammatory markers. The Zn (II) modification notably improved the anti-inflammatory effects, suggesting GP–Zn (II) complexes as potential agents for treating chronic inflammation-related diseases.