Catecholaminergic Neurons Enhance Fibroblast Osteogenic Activity in Keloid

May 2026 in “ Nature Communications ”

Fangzhou Lou, Jihuan Liang, Yang SUN, Fengjiao Zhang, Xiaojie CAI, Siyu Deng, Zhenyao Xu, Qili PENG, Aie Xu, Rui CHEN, Honglin Wang

catecholaminergic neurons fibroblast osteogenic activity keloid catecholamine neurotransmitters epinephrine ADRB1 receptor mRNA transporter Translin metoprolol adrenaline beta-1 adrenergic receptor Translin beta-blocker

Studysummary In this study, researchers identified that keloid fibroblasts respond to neurotransmitters from catecholaminergic nerves by producing bone matrix proteins, mediated by β1-adrenergic receptor activation, leading to fibro-osseous reprogramming; blocking this signaling in a rodent model prevented the development of keloid-like pathology.

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