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This research concludes that adipose mesenchymal stem cells are uniquely evolved to manage skin inflammation in newborns and their released molecules are the safest and most effective for skin therapeutics.

The systematic review reported promising outcomes for stem cell-enriched treatments in aesthetic medicine, such as improved skin rejuvenation, hair restoration, and scar revision. However, challenges like protocol variability and regulatory issues must be addressed to ensure effective and safe clinical applications.

In this study of clinical-grade ADMSCs, researchers found that cells expanded in PowerStem MSC1 media exhibited increased negative marker expression, chromosomal abnormalities, and signs of senescence compared to those cultured in StemMACS MSC Expansion Media, suggesting that the latter is more suitable for therapeutic applications.

In this study, researchers found that hypoxic preconditioning significantly improved the regenerative potential of aged adipose-derived mesenchymal stem cells, enhancing their growth, differentiation, and pro-angiogenic capabilities, suggesting a promising strategy for autologous regenerative medicine applications.

This review highlights that exosomes from adipose-derived stem cells, particularly those enriched with circ-Ash1l, can inhibit ferroptosis and reduce UVB-induced skin aging by delivering GPX4-promoting signals to damaged cells, thus offering a potential regenerative therapy for photoaged skin.

This review reports significant advancements in plastic surgery using stem cell therapies for aesthetic and reconstructive applications, including grafting and wound healing, though it underscores the need for continued research to address regulatory, ethical, and standardization issues.

This study discovered that exosomes from adipose-derived mesenchymal stem cells can mitigate damage in dermal papilla cells by modulating the TGF-β1/SMAD2 signaling pathway through miRNAs miR-574-3p and miR-125a-5p, revealing potential therapeutic targets for androgenetic alopecia.

This review discusses the application of mesenchymal stem cells and their secretory factors for skin and hair regeneration and reports no clinical results; the authors highlight the progress and call for practical applications.

This chapter reviews the potential of adipose-derived stem cells for skin aging and hair loss treatments but reports no new experimental results; the authors highlight these stem cells as a promising regenerative resource.

This review covers the potential of SVF and ADSC therapies in regenerative medicine and highlights the challenges of regulation and efficacy, without reporting new clinical results.

This study found that subcutaneous administration of conditioned medium from adipose-derived stem cells promoted hair growth in mice, and hypoxia enhanced this effect by altering growth factor secretion.

This study found that exosome-incorporated human amniotic membrane scaffolds notably enhanced diabetic skin wound healing in mice, suggesting potential applications for ADSC-derived exosomes in clinical settings.

This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.

This study found that adipose-derived stem cell extracellular vesicles reduced wrinkles and promoted cell proliferation in UVB-induced photoaging in mice by decreasing oxidative stress and inflammation.

This retrospective study found that adipose-derived stem cell-conditioned media increased hair density and thickness in women with female pattern hair loss over 12 weeks, with no severe adverse effects reported.

This review discusses the paracrine effects of adipose tissue-derived stem cells on surrounding cells and tissues, noting their potential therapeutic benefits, but reports no new clinical results.

This review discusses the potential applications of adipose-derived stromal cells for treating conditions like colitis, liver failure, and more, without presenting new clinical results.

This review provides an overview of current research on AD-MSCs, PRP, and biomaterials, highlighting their safety and efficacy in treating soft tissue defects and chronic wounds without major side effects.

In this study, Japanese patients treated with adipose-derived stem cell-conditioned medium for hair regeneration showed positive outcomes, suggesting it may be an effective new therapy for alopecia.

This review examines the effects of adipose-derived stem cells and their secreted factors on hair growth stimulation in laboratory and animal models, suggesting their potential as therapeutic agents for hair loss treatment.

This study reports that adipose-derived stem cells can protect against radiation-induced dermatitis in rats by reducing apoptosis through lowering Cathepsin F expression, suggesting a potential new therapeutic approach.

This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.

This study found that a dopamine-methacrylated hyaluronic acid hydrogel enhances the efficacy of adipose-derived stem cells in promoting skin regeneration, potentially involving the Notch signaling pathway.

This review explores the potential of using genetically-manipulated stem cells as both therapeutic agents and gene delivery vehicles for enhanced wound regeneration, but it reports no new clinical results.

This study found that intradermal administration of adipose-derived stem cell–conditioned medium significantly increased hair density and dermal thickness, suggesting potential regenerative effects on both hair follicles and the interfollicular scalp in patients with alopecia.

This review discusses current experimental research on the use of stem cells, particularly ADSCs and BM-MSCs, in plastic and reconstructive surgery but reports no new clinical findings.

This review discusses the potential of adipose-derived stem cells for hair regeneration and suggests that these cells and their conditioned media may offer a promising strategy for treating hair loss.

This study reported that treatments using ADSC-CM improved hair growth in all participants, with the most pronounced results after four sessions within three to four months.

In this randomized clinical trial, the authors reported that adipose-derived stem cell constituent extract topical solution increased hair density and thickness in patients with androgenetic alopecia over 16 weeks compared to placebo.

This study found that adipose-derived stem cells from HIV-infected patients with lipodystrophy associated with HAART demonstrated similar growth and differentiation potential as those from HIV-uninfected patients, suggesting potential for autologous regenerative therapy.