Testosterone-Induced Androgenetic Alopecia Mice Model: A Preliminary Study

    June 2025 in “ International Journal of Applied Pharmaceutics ”
    Arie Kusumawardani, Nurrachmat Mulianto, Adniana Nareswari … Trya Oktaviani
    Studysummary This study developed a testosterone-induced androgenetic alopecia model in BALB/c mice, finding that a 0.075 ml testosterone injection best replicated the dermal and hair follicle conditions of AGA patients, providing a promising tool for future drug testing and research into AGA therapies.
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    Research cited in this study 29

    1. Solid Lipid Nanoparticles of Fenugreek Seed Extract in a Dermatological Base for Alopecia: An In Vivo Study International Journal of Applied Pharmaceutics · 2024
    2. High-Frequency Ultrasonography of the Scalp: A Comparison Between Androgenetic Alopecia and Healthy Volunteers Skin Research and Technology · 2024
    3. Androgenetic Alopecia in Men: An Update on Genetics Indian Journal of Dermatology · 2024
    4. Does Androgenic Alopecia Aggravate the Risk of Prostate Cancer? Evidence from Mendelian Randomization Prostate international · 2024
    5. Androgenetic Alopecia: A Review Nigerian Postgraduate Medical Journal · 2024
    6. The Hormonal Background of Hair Loss in Non-Scarring Alopecias Biomedicines · 2024
    7. Uncovering the Genetic Architecture and Evolutionary Roots of Androgenetic Alopecia in African Men bioRxiv (Cold Spring Harbor Laboratory) · 2024
    8. Status of Research on the Development and Regeneration of Hair Follicles International Journal of Medical Sciences · 2023
    9. Efficacy of Derinat as a Treatment for Murine and Androgenetic Alopecia Patients Translational Medicine Communications · 2023
    10. Astragalus Membranaceus and Cinnamomum Cassia Stimulate Hair Follicle Differentiation-Related Growth Factor via Wnt/Beta-Catenin Pathway Current Issues in Molecular Biology · 2023
    11. Androgenetic Alopecia: An Update JAAD International · 2023
    12. Androgenetic Alopecia: Therapy Update Drugs · 2023
    13. Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs Clinical, Cosmetic and Investigational Dermatology · 2023
    14. Process Validation of Beta-Sitosterol Hair Gel Formulation and Evaluation of 5 Alpha Reductase Inhibition In Vitro for the Treatment of Androgenetic Alopecia International Journal of Applied Pharmaceutics · 2023
    15. Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss Journal of Clinical Medicine · 2023
    16. The AR/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia International Journal of Biological Sciences · 2023
    17. Comorbidities in Androgenetic Alopecia: A Comprehensive Review Dermatology and therapy · 2022
    18. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    19. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    20. Design of In Vitro Hair Follicles for Different Applications in the Treatment of Alopecia: A Review Biomedicines · 2021
    21. In Vivo Phytotherapy in BALB/c Athymic Nude Mice: Hair Growth Promotion Using Ficus Religiosa L. and Morus Alba L. Journal of Natural Remedies · 2021
    22. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    23. Hormonal Effects on Hair Follicles International journal of molecular sciences · 2020
    24. MR Imaging of Hair and Scalp for the Evaluation of Androgenetic Alopecia Magnetic Resonance in Medical Sciences · 2020
    25. A Novel Effect of Acyclovir on Hair Growth in BALB/c Mice: A Promising Future for Finding a New Topical Drug for the Treatment of Hirsutism Clinical, Cosmetic and Investigational Dermatology · 2020
    26. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    27. Female Androgenetic Alopecia: An Update on Diagnosis and Management American Journal of Clinical Dermatology · 2019
    28. Quality of Life Assessment in Patients with Androgenetic Alopecia International Journal of Trichology · 2019
    29. Evaluation of Animal Models Suitable for Hair Research and Regeneration InTech eBooks · 2018

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