Testosterone-Induced Androgenetic Alopecia Mice Model: A Preliminary Study

This preliminary study successfully developed a testosterone-induced androgenetic alopecia (AGA) model using BALB/c mice, which could be instrumental for future research and drug testing for AGA therapies. By administering subcutaneous injections of testosterone at doses of 0.05 ml, 0.075 ml, and 0.1 ml, researchers identified that the 0.075 ml dose was most effective in mimicking AGA conditions, as it resulted in the most significant reduction in dermal thickness (385.59 μm) and hair follicle density (13.38/mm²). This model holds potential for advancing the understanding of AGA pathophysiology and the development of new treatments.