Uncovering the Genetic Architecture and Evolutionary Roots of Androgenetic Alopecia in African Men

    January 2024 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Rohini Janivara, Ujani Hazra, Aaron Pfennig … Joseph Lachance

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that genetic predictions of male pattern baldness derived from European data do not accurately predict baldness in African populations, highlighting significant continental differences in genetic architecture and evolutionary history.
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    Research cited in this study 14

    1. Analysis of 72,469 UK Biobank Exomes Links Rare Variants to Male-Pattern Hair Loss Nature Communications · 2023
    2. Genetic Prediction of Male Pattern Baldness Based on Large Independent Datasets European Journal of Human Genetics · 2022
    3. Comorbidities in Androgenetic Alopecia: A Comprehensive Review Dermatology and therapy · 2022
    4. Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness Nature Communications · 2018
    5. GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk Nature Communications · 2017
    6. Androgenetic Alopecia: A Review Endocrine · 2017
    7. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    8. Genetic Prediction of Male Pattern Baldness PLoS Genetics · 2017
    9. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    10. Prevalence and Etiology of Central Centrifugal Cicatricial Alopecia Archives of Dermatology · 2011
    11. Recent Positive Selection of a Human Androgen Receptor/Ectodysplasin A2 Receptor Haplotype and Its Relationship to Male Pattern Baldness Human Genetics · 2009
    12. Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11 Nature Genetics · 2008
    13. Family History and Risk of Hair Loss Dermatology · 2004
    14. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001