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GlossaryEDAR gene

provides instructions for a protein crucial in hair development

The EDAR gene provides instructions for making a protein that is crucial for the development of hair, teeth, and sweat glands. Mutations in this gene can lead to conditions like hypohidrotic ectodermal dysplasia, which affects these structures, resulting in sparse hair, missing teeth, and reduced ability to sweat.

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research Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss

38 citations, February 2012 in “British Journal of Dermatology”

AR/EDA2R gene linked to early-onset female hair loss, but 20p11 gene not involved.

research EDA2R Is Associated With Androgenetic Alopecia

82 citations, September 2008 in “Journal of Investigative Dermatology”

EDA2R gene linked to hair loss.

A Tale of Two Haplotypes: The EDA2R/AR Intergenic Region Is the Most Divergent Genomic Segment Between Africans and East Asians in the Human Genome

research A Tale of Two Haplotypes: The EDA2R/AR Intergenic Region Is the Most Divergent Genomic Segment Between Africans and East Asians in the Human Genome

4 citations, December 2012 in “Human Biology”

The most different genetic segment between Africans and East Asians is the EDA2R/AR region, with two main types influenced by population changes and natural selection, and linked to baldness.

research P53-Dependent Transcriptional Regulation of EDA2R and Its Involvement in Chemotherapy-Induced Hair Loss

37 citations, April 2010 in “FEBS Letters”

The study concludes that the EDA2R gene is activated by p53 during chemotherapy but is not necessary for chemotherapy-induced hair loss.

research Uncovering the Genetic Architecture and Evolutionary Roots of Androgenetic Alopecia in African Men

January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research found that genetic factors for male pattern baldness in African men differ significantly from those in Europeans.

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community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 41 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.