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GlossaryEDARADD gene

gene involved in hair, teeth, and sweat gland development

The EDARADD gene provides instructions for making a protein that interacts with the EDAR protein, which is crucial for the development of hair, teeth, and sweat glands. Mutations in this gene can lead to conditions like hypohidrotic ectodermal dysplasia, which affects the normal development of these structures.

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research Novel Missense Mutation in the EDA Gene in a Family Affected by Oligodontia

12 citations, January 2016 in “Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie”

Researchers found a new mutation in the EDA gene that likely causes missing teeth and mild skin symptoms in one family.

research Advances in the Genetic Understanding of Hypohidrotic Ectodermal Dysplasia

1 citations, November 2017 in “Expert opinion on orphan drugs”

Scientists now better understand the genetics of hypohidrotic ectodermal dysplasia, leading to more accurate diagnoses and potential new treatments.

research Biology and Genetics of Hair

89 citations, September 2010 in “Annual Review of Genomics and Human Genetics”

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

research Ancient Lineages of the Keratin-Associated Protein (KRTAP) Genes and Their Co-option in the Evolution of the Hair Follicle

November 2022 in “Research Square (Research Square)”

Keratin-associated proteins have ancient origins and were used for different purposes before being adapted for hair in mammals.

research WNT10A, Dermatology and Dentistry

30 citations, June 2021 in “British Journal of Dermatology”

Mutations in the WNT10A gene can cause skin, hair, teeth, and other disorders, and may also affect other areas like kidney and cancer, with potential for targeted treatments.

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