Process Validation of Beta-Sitosterol Hair Gel Formulation and Evaluation of 5 Alpha Reductase Inhibition In Vitro for the Treatment of Androgenetic Alopecia

    March 2023 in “ International Journal of Applied Pharmaceutics ”
    ARPAN CHAKRABORTY, Arka Bhattacharjee, MANAS CHAKRABORTY, GOUTAM MUKHOPADHYAY
    Studysummary In this study, researchers formulated a topical gel containing β-sitosterol for alopecia treatment and found it demonstrated good 5 alpha reductase inhibitory activity in vitro, comparable to a commercial product, indicating its potential for further antiandrogenic activity investigation.
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    Research cited in this study 12

    1. Microneedle Mediated Transdermal Delivery of Beta-Sitosterol Loaded Nanostructured Lipid Nanoparticles for Androgenic Alopecia Drug Delivery · 2022
    2. Formulation and Evaluation of Herbal Hair Gel Scholars international journal of traditional and complementary medicine · 2022
    3. Identification of Beta-Sitosterol and Stigmasterol as Possible Inhibitors of 5 Alpha-Reductase 1: An In-Silico Study Precision medicine and clinical omics · 2022
    4. Improvement of Alopecia and Decreases in Hair Cortisol and Dihydrotestosterone Concentrations After the Topical Use of Plant Extracts in Men With Androgenetic Alopecia Asian Journal of Pharmaceutical and Clinical Research · 2021
    5. Microbial Oxidation of Finasteride with Macrophomina Phaseolina (KUCC 730) International Journal of Pharmacy and Pharmaceutical Sciences · 2017
    6. Evaluation of 5α-Reductase Inhibitory Activity of Certain Herbs Useful as Antiandrogens Andrologia · 2013
    7. Development and Characterization of Phyto-Vesicles of Beta-Sitosterol for the Treatment of Androgenetic Alopecia Archives of Dermatological Research · 2011
    8. Hair Growth Promoting Activity of Eclipta Alba in Male Albino Rats Archives of Dermatological Research · 2008
    9. A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia Journal of Alternative and Complementary Medicine · 2002
    10. A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia Journal of Alternative and Complementary Medicine · 2002
    11. Hair and Systemic Disease Dermatologic Clinics · 2001
    12. PNU 157706, A Novel Dual Type I and II 5α-Reductase Inhibitor The Journal of Steroid Biochemistry and Molecular Biology · 1998

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