Efficacy of Derinat as a Treatment for Murine and Androgenetic Alopecia Patients

November 2023 in “ Translational Medicine Communications ”

Chia‐Hung Wu, Wei-Chiao Chen, Chia-Hsun Hsieh, Yun‐Fang Liang, Weiju Li, Heqing Shen, Wei-Yen Wei, Ting-Yu Chou, Yen-Chun Chiu, Hao Huang, Wen‐Li Hsu

Derinat TRPCs inhibitor androgenetic alopecia AGA oxidative stress anagen phase reactive oxygen species ROS hair cycle bioinformatics analysis inflammation hair density hair diameter

Studysummary In this study, researchers found that Derinat, a TRPCs inhibitor, reduced oxidative stress and prolonged the anagen phase of hair growth in mice, supporting its potential as a therapy for androgenetic alopecia by improving clinical outcomes and enhancing quality of life for those affected.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study investigated the efficacy of Derinat, a TRPCs inhibitor, in treating Androgenetic alopecia (AGA), a common type of hair loss. The research found that Derinat extended the lifespan of Caenorhabditis elegans worms by restraining oxidative stress-induced aging. In mice, Derinat maintained the hair cycle at the anagen phase by reducing TRPCs-mediated reactive oxygen species (ROS) accumulation. Bioinformatics analysis confirmed AGA pathogenesis is associated with TRPCs-regulated oxidative stress and inflammation. In clinical trials involving AGA patients aged 20 to 75, Derinat treatment improved the outcomes of oral medication, increasing hair density and diameter after 4 and 8 weeks of use, and mitigated the impairment of their quality of life. The study concluded that Derinat has potential anti-oxidative stress efficacy that extends hair growth patterns and maintains the hair cycle at the anagen phase.

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