Efficacy of Derinat as a Treatment for Murine and Androgenetic Alopecia Patients

    Chia‐Hung Wu, Wei-Chiao Chen, Chia-Hsun Hsieh, Yun‐Fang Liang, Weiju Li, Heqing Shen, Wei-Yen Wei, Ting-Yu Chou, Yen-Chun Chiu, Hao Huang, Wen‐Li Hsu
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    TLDR Derinat may improve hair growth and quality of life in hair loss patients by reducing oxidative stress.
    The study investigated the efficacy of Derinat, a TRPCs inhibitor, in treating Androgenetic alopecia (AGA), a common type of hair loss. The research found that Derinat extended the lifespan of Caenorhabditis elegans worms by restraining oxidative stress-induced aging. In mice, Derinat maintained the hair cycle at the anagen phase by reducing TRPCs-mediated reactive oxygen species (ROS) accumulation. Bioinformatics analysis confirmed AGA pathogenesis is associated with TRPCs-regulated oxidative stress and inflammation. In clinical trials involving AGA patients aged 20 to 75, Derinat treatment improved the outcomes of oral medication, increasing hair density and diameter after 4 and 8 weeks of use, and mitigated the impairment of their quality of life. The study concluded that Derinat has potential anti-oxidative stress efficacy that extends hair growth patterns and maintains the hair cycle at the anagen phase.
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