Efficacy of Derinat as a Treatment for Murine and Androgenetic Alopecia Patients

    November 2023 in “ Translational Medicine Communications ”
    Chia‐Hung Wu, Wei-Chiao Chen, Chia-Hsun Hsieh … Wen‐Li Hsu
    Studysummary In this study, researchers found that Derinat, a TRPCs inhibitor, reduced oxidative stress and prolonged the anagen phase of hair growth in mice, supporting its potential as a therapy for androgenetic alopecia by improving clinical outcomes and enhancing quality of life for those affected.
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    Research cited in this study 19

    1. Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways Frontiers in Medicine · 2022
    2. Cyanidin 3-O-Arabinoside Suppresses DHT-Induced Dermal Papilla Cell Senescence by Modulating p38-Dependent ER-Mitochondria Contacts Journal of Biomedical Science · 2022
    3. A Systematic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia Natural Products and Bioprospecting · 2020
    4. At The Crossroads Of Two Alopecias: Androgenetic Alopecia Pattern Of Hair Regrowth In Patients With Alopecia Areata Treated With Oral Janus Kinase Inhibitors JAAD case reports · 2020
    5. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    6. Quality of Life Assessment in Patients with Androgenetic Alopecia International Journal of Trichology · 2019
    7. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    8. Demographics of Women with Female Pattern Hair Loss and the Effectiveness of Spironolactone Therapy Journal of The American Academy of Dermatology · 2015
    9. Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress During Hair Cycling PloS one · 2015
    10. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    11. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    12. Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness? Experimental Dermatology · 2014
    13. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    14. Exogenous Stimulations Change Nude Mouse Hair Cycle Pattern Journal of dermatological treatment · 2010
    15. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    16. Oxidative Stress in Aging of Hair International Journal of Trichology · 2009
    17. Family History and Risk of Hair Loss Dermatology · 2004
    18. Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    19. Modeling the Dynamics of Human Hair Cycles by a Follicular Automaton Proceedings of the National Academy of Sciences · 2000

    Related research 7

    1. A Review of Hair Anatomy and Animal Models for Alopecia Recent Trends in Pharmaceutical Sciences and Research · 2023
    2. Hair Loss: Causes and Pathology International Journal of Research in Medical Sciences & Technology · 2021
    3. Drug-Induced Alopecia 2015
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    5. Alopecia Journal of the Korean Medical Association · 2002
    6. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    7. Treatment of Hair Loss The New England Journal of Medicine · 1999