Efficacy of Derinat as a Treatment for Murine and Androgenetic Alopecia Patients

November 2023 in “ Translational Medicine Communications ”

Chia‐Hung Wu, Wei-Chiao Chen, Chia-Hsun Hsieh, Yun‐Fang Liang, Weiju Li, Heqing Shen, Wei-Yen Wei, Ting-Yu Chou, Yen-Chun Chiu, Hao Huang, Wen‐Li Hsu

Derinat TRPCs inhibitor androgenetic alopecia AGA oxidative stress anagen phase reactive oxygen species ROS hair cycle bioinformatics analysis inflammation hair density hair diameter

TLDR Derinat may improve hair growth and quality of life in hair loss patients by reducing oxidative stress.

The study investigated the efficacy of Derinat, a TRPCs inhibitor, in treating Androgenetic alopecia (AGA), a common type of hair loss. The research found that Derinat extended the lifespan of Caenorhabditis elegans worms by restraining oxidative stress-induced aging. In mice, Derinat maintained the hair cycle at the anagen phase by reducing TRPCs-mediated reactive oxygen species (ROS) accumulation. Bioinformatics analysis confirmed AGA pathogenesis is associated with TRPCs-regulated oxidative stress and inflammation. In clinical trials involving AGA patients aged 20 to 75, Derinat treatment improved the outcomes of oral medication, increasing hair density and diameter after 4 and 8 weeks of use, and mitigated the impairment of their quality of life. The study concluded that Derinat has potential anti-oxidative stress efficacy that extends hair growth patterns and maintains the hair cycle at the anagen phase.

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Research cited in this study

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