Does Androgenic Alopecia Aggravate the Risk of Prostate Cancer? Evidence from Mendelian Randomization

April 2024 in “ Prostate international ”

Xianghua Shi, Yuan Pan, Jianhua Liu, Fei Luo, Binbin Li, Yuan Hu, Kai Chen

androgenic alopecia prostate cancer Mendelian randomization genome-wide association studies single nucleotide polymorphisms AGA PC GWAS SNPs

TLDR Male pattern baldness does not cause an increased risk of prostate cancer.

The study "Does Androgenic Alopecia Aggravate the Risk of Prostate Cancer? Evidence from Mendelian Randomization" used Mendelian randomization analysis to explore a potential causal relationship between androgenic alopecia (AGA) and prostate cancer (PC). Using public genome-wide association studies summary data for single nucleotide polymorphisms associated with AGA, the study found no causal effect of genetically proxied AGA on PC risk. This suggests that associations observed in previous epidemiological studies may not be causal. The study was financially supported by the GuangDong Basic and Applied Basic Research Foundation.

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