Relationship Between Male Pattern Baldness and the Risk of Aggressive Prostate Cancer: An Analysis of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

September 2014 in “ Journal of Clinical Oncology ”

Cindy Ke Zhou, Ruth M. Pfeiffer, Sean D. Cleary, Heather J. Hoffman, Paul H. Levine, Lisa W. Chu, Ann W. Hsing, Michael B. Cook

male pattern baldness frontal baldness vertex baldness aggressive prostate cancer pathophysiologic mechanisms baldness hair loss

Studysummary This study observed that frontal plus moderate vertex baldness at age 45 was associated with a higher risk of aggressive prostate cancer in a large cohort.

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research Relationship of Early-Onset Baldness to Prostate Cancer in African-American Men

21 citations , March 2013 in “Cancer Epidemiology, Biomarkers & Prevention”

This study found that early-onset baldness in African-American men is associated with an increased risk of developing prostate cancer and more aggressive tumors, with potential interactions involving age and smoking.

research Androgenetic Alopecia at Various Ages and Prostate Cancer Risk in an Equal-Access Multiethnic Case-Control Series of Veterans

12 citations , March 2013 in “Cancer Causes & Control”

This study found that an earlier onset of androgenetic alopecia, especially in a frontal balding pattern, was significantly associated with an increased risk of prostate cancer among men at a Veterans Affairs Hospital.

research Androgenetic Alopecia and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis

34 citations , February 2013 in “Journal of The American Academy of Dermatology”

This meta-analysis found that vertex pattern androgenetic alopecia was associated with an increased risk of developing prostate cancer, while other androgenetic alopecia patterns did not show a significant link.

research Age-Dependent Associations Between Androgenetic Alopecia and Prostate Cancer Risk

17 citations , November 2012 in “Cancer Epidemiology, Biomarkers & Prevention”

This study observed that men with vertex androgenetic alopecia at age 40 had a higher risk of early-onset prostate cancer, suggesting a potential link between the conditions.

research Male Pattern Baldness and the Risk of Prostate Cancer

38 citations , February 2011 in “Annals of Oncology”

This study found that early-onset androgenic alopecia is associated with a higher risk of developing prostate cancer, although it was not linked to earlier diagnosis or more aggressive tumors.

research Androgenetic Alopecia and Cardiovascular Risk Factors in Men and Women: A Comparative Study

110 citations , July 2010 in “Journal of The American Academy of Dermatology”

Hair loss linked to higher heart disease risk in both men and women.

research Androgenic Alopecia Is Not Useful as an Indicator of Men at High Risk of Prostate Cancer

28 citations , June 2010 in “European Journal of Cancer”

This study found that androgenic alopecia at an early age was associated with a lower risk of prostate cancer, contrary to assumptions about androgens' role.

research Male Pattern Baldness and Prostate Cancer Risk in a Population-Based Case-Control Study

29 citations , March 2010 in “Cancer epidemiology”

This study found that early-onset male pattern baldness was associated with a reduced relative risk of prostate cancer.

research Androgens and Hair Loss: An In-Depth Analysis of Androgenetic Alopecia

52 citations , June 2009 in “Current Opinion in Endocrinology, Diabetes and Obesity”

This review discusses the pathogenesis and treatment of androgenetic alopecia, highlighting genome associations and newer topical formulations, but reports no new clinical results.

research Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26

62 citations , March 2008 in “American Journal of Human Genetics”

This study located a potential genetic link for androgenetic alopecia on chromosome 3q26, marking an early step in identifying new susceptibility genes for male pattern baldness.

Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

research Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

60 citations , January 2007 in “Human Genetics”

In this study, researchers found that while the SNP rs6152 is strongly associated with androgenetic alopecia, the GGN triplet repeat is not, suggesting the causative variant is likely a non-coding one.

research Changes in Hair Weight in Men with Androgenetic Alopecia After Treatment with Finasteride (1 mg Daily): Three- and Four-Year Results

66 citations , June 2006 in “Journal of The American Academy of Dermatology”

This study found that long-term finasteride treatment in men with androgenetic alopecia significantly increased hair weight and count compared to placebo over nearly four years.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Validity of Self-Reported Male Balding Patterns in Epidemiological Studies

32 citations , December 2004 in “BMC Public Health”

This study found that trained observers using the Hamilton-Norwood classification were very reliable in assessing balding patterns, while men's self-assessments were moderately accurate compared to observers.

research Genetic Basis of Male Pattern Baldness

191 citations , December 2003 in “Journal of Investigative Dermatology”

Male pattern baldness is largely genetic, linked to the androgen receptor gene, and may relate to certain health issues.

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

299 citations , March 2001 in “Journal of Investigative Dermatology”

This study found that specific genetic markers near the androgen receptor gene are significantly more common in men with male pattern baldness, suggesting a genetic component in its development.

research Vertex Balding, Plasma Insulin-Like Growth Factor 1, and Insulin-Like Growth Factor Binding Protein 3

26 citations , June 2000 in “Journal of The American Academy of Dermatology”

This study found that older men with vertex balding had lower levels of IGFBP-3 and higher levels of IGF-1 in their plasma.

research Risk Factors for Prostate Cancer: A Case-Control Study in Greece

127 citations , March 1999 in “International Journal of Cancer”

This study from Athens, Greece observed that urban living may increase prostate cancer risk, while early adulthood sexual activity might inversely relate to this risk.

research Cultured Dermal Papilla Cells From Androgen-Dependent Human Hair Follicles Contain More Androgen Receptors Than Those From Non-Balding Areas Of Scalp

124 citations , April 1992 in “Journal of Endocrinology/Journal of endocrinology”

This study observed that cells from androgen-sensitive areas like the beard and scrotum showed higher androgen receptor levels compared to those from non-balding scalp areas, supporting the role of dermal papilla in follicle growth responses to androgens.

research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-Pattern Baldness

51 citations , January 1989 in “Journal of Investigative Dermatology”

This study found that sebaceous glands in bald scalp have greater androgen binding affinity and capacity than those in hairy scalp, possibly contributing to the androgenic response seen in male pattern baldness.