21 citations
,
March 2013 in “Cancer Epidemiology, Biomarkers & Prevention” This study found that early-onset baldness in African-American men is associated with an increased risk of developing prostate cancer and more aggressive tumors, with potential interactions involving age and smoking.
12 citations
,
March 2013 in “Cancer Causes & Control” This study found that an earlier onset of androgenetic alopecia, especially in a frontal balding pattern, was significantly associated with an increased risk of prostate cancer among men at a Veterans Affairs Hospital.
34 citations
,
February 2013 in “Journal of The American Academy of Dermatology” This meta-analysis found that vertex pattern androgenetic alopecia was associated with an increased risk of developing prostate cancer, while other androgenetic alopecia patterns did not show a significant link.
17 citations
,
November 2012 in “Cancer Epidemiology, Biomarkers & Prevention” This study observed that men with vertex androgenetic alopecia at age 40 had a higher risk of early-onset prostate cancer, suggesting a potential link between the conditions.
38 citations
,
February 2011 in “Annals of Oncology” This study found that early-onset androgenic alopecia is associated with a higher risk of developing prostate cancer, although it was not linked to earlier diagnosis or more aggressive tumors.
110 citations
,
July 2010 in “Journal of The American Academy of Dermatology” Hair loss linked to higher heart disease risk in both men and women.
28 citations
,
June 2010 in “European Journal of Cancer” This study found that androgenic alopecia at an early age was associated with a lower risk of prostate cancer, contrary to assumptions about androgens' role.
29 citations
,
March 2010 in “Cancer epidemiology” This study found that early-onset male pattern baldness was associated with a reduced relative risk of prostate cancer.
52 citations
,
June 2009 in “Current Opinion in Endocrinology, Diabetes and Obesity” This review discusses the pathogenesis and treatment of androgenetic alopecia, highlighting genome associations and newer topical formulations, but reports no new clinical results.
62 citations
,
March 2008 in “American Journal of Human Genetics” This study located a potential genetic link for androgenetic alopecia on chromosome 3q26, marking an early step in identifying new susceptibility genes for male pattern baldness.
60 citations
,
January 2007 in “Human Genetics” In this study, researchers found that while the SNP rs6152 is strongly associated with androgenetic alopecia, the GGN triplet repeat is not, suggesting the causative variant is likely a non-coding one.
66 citations
,
June 2006 in “Journal of The American Academy of Dermatology” This study found that long-term finasteride treatment in men with androgenetic alopecia significantly increased hair weight and count compared to placebo over nearly four years.
195 citations
,
June 2005 in “American Journal of Human Genetics” Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.
32 citations
,
December 2004 in “BMC Public Health” This study found that trained observers using the Hamilton-Norwood classification were very reliable in assessing balding patterns, while men's self-assessments were moderately accurate compared to observers.
191 citations
,
December 2003 in “Journal of Investigative Dermatology” Male pattern baldness is largely genetic, linked to the androgen receptor gene, and may relate to certain health issues.
299 citations
,
March 2001 in “Journal of Investigative Dermatology” This study found that specific genetic markers near the androgen receptor gene are significantly more common in men with male pattern baldness, suggesting a genetic component in its development.
26 citations
,
June 2000 in “Journal of The American Academy of Dermatology” This study found that older men with vertex balding had lower levels of IGFBP-3 and higher levels of IGF-1 in their plasma.
127 citations
,
March 1999 in “International Journal of Cancer” This study from Athens, Greece observed that urban living may increase prostate cancer risk, while early adulthood sexual activity might inversely relate to this risk.
124 citations
,
April 1992 in “Journal of Endocrinology/Journal of endocrinology” This study observed that cells from androgen-sensitive areas like the beard and scrotum showed higher androgen receptor levels compared to those from non-balding scalp areas, supporting the role of dermal papilla in follicle growth responses to androgens.
51 citations
,
January 1989 in “Journal of Investigative Dermatology” This study found that sebaceous glands in bald scalp have greater androgen binding affinity and capacity than those in hairy scalp, possibly contributing to the androgenic response seen in male pattern baldness.