Relationship Between Male Pattern Baldness and the Risk of Aggressive Prostate Cancer: An Analysis of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

    September 2014 in “ Journal of Clinical Oncology
    Cindy Ke Zhou, Ruth M. Pfeiffer, Sean D. Cleary, Heather J. Hoffman, Paul H. Levine, Lisa W. Chu, Ann W. Hsing, Michael B. Cook
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    TLDR Men with baldness at the front and top of their head at age 45 may have a higher risk of aggressive prostate cancer.
    The study from 2015 within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial cohort, which included 39,070 men, found that frontal plus moderate vertex baldness at age 45 was significantly associated with an increased risk of aggressive prostate cancer, with a hazard ratio (HR) of 1.39 (95% CI, 1.07 to 1.80). Other patterns of baldness were not significantly associated with aggressive prostate cancer, nor with overall or nonaggressive prostate cancer. The study suggests that there may be shared pathophysiologic mechanisms between male pattern baldness and aggressive prostate cancer, although it also acknowledges limitations such as the reliability of baldness classification and the retrospective nature of baldness recall by participants.
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