Real-World Evidence in Alopecia Areata Treatment: A Narrative Review

    October 2025 in “ Dermatologica Sinica ”
    C. C. Tsai, Feng‐Ling Lin, Ting-Ting Cheng, Yang Lo
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    TLDR A personalized treatment combining traditional and new therapies may improve hair loss outcomes in alopecia areata.
    The narrative review on alopecia areata (AA) treatment discusses the complexity of managing this autoimmune disorder, affecting 0.5%-2% of the global population. Traditional treatments like corticosteroids and minoxidil have mixed results, while novel therapies such as JAK inhibitors show promise, particularly in moderate-to-severe cases. However, high relapse rates and side effects remain challenges. Combination therapies, including methotrexate and cyclosporine with corticosteroids, improve outcomes in severe cases but also increase side effects. Pediatric treatments require careful management. Emerging therapies like dupilumab and phototherapy show potential but need more evidence. The review highlights the necessity for large-scale trials to establish long-term efficacy and safety, advocating for personalized treatment approaches.
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