Multifunctional Nanomedicine Targeting the 'Seed-and-Soil' of Hair Follicles via Simultaneous Alleviation of Oxidative Stress and Activation of Autophagy for Androgenetic Alopecia Therapy

    July 2025 in “ Materials Today Bio ”
    Yuanzheng Chen, Qubo Zhu, Yanbin Zhou … Yan Chen
    Studysummary This study suggests that curcumin-loaded nanoparticles, which activate autophagy and reduce oxidative stress, showed promise in promoting hair growth in an androgenetic alopecia mouse model.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 27

    1. Gas-Propelled Anti-Hair Follicle Aging Microneedle Patch for the Treatment of Androgenetic Alopecia Journal of Controlled Release · 2025
    2. Hybrid Hair Follicle Stem Cell Extracellular Vesicles Co-Delivering Finasteride and Gold Nanoparticles for Androgenetic Alopecia Treatment Journal of Controlled Release · 2024
    3. Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia Nano letters · 2024
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    6. Bioinspired Engineering of ADSC Nanovesicles in Thermosensitive Hydrogel to Enhance Autophagy of Dermal Papilla Cells for Androgenetic Alopecia Treatment Bioactive Materials · 2024
    7. Traditional Scraping Combined with Copper-Curcumin Nanoparticle Oleogel for Therapy of Androgenic Alopecia Advanced Healthcare Materials · 2024
    8. Topically Applied Magnetized Saline Water Activates Autophagy in the Scalp and Increases Hair Count and Hair Mass Index in Men With Mild-to-Moderate Androgenetic Alopecia Cureus · 2023
    9. Hdac1 and Hdac2 Regulate the Quiescent State and Survival of Hair-Follicle Mesenchymal Niche Nature communications · 2023
    10. Dissolving Microneedle Patch Integrated With Microspheres For Long-Acting Hair Regrowth Therapy ACS Applied Materials & Interfaces · 2023
    11. Protac Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration Small methods · 2022
    12. Limonin, a Component of Immature Citrus Fruits, Activates Anagen Signaling in Dermal Papilla Cells Nutrients · 2022
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    17. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    18. Argan (Argania Spinosa) Press Cake Extract Enhances Cell Proliferation and Prevents Oxidative Stress and Inflammation of Human Dermal Papilla Cells Journal of dermatological science · 2021
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    20. Neural Progenitor Cell-Derived Nanovesicles Promote Hair Follicle Growth via miR-100 Journal of nanobiotechnology · 2021
    21. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    22. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    23. Hydroxytyrosol Prevents Dermal Papilla Cells Inflammation Under Oxidative Stress by Inducing Autophagy Journal of Biochemical and Molecular Toxicology · 2019
    24. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    25. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    26. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
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