Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling

    Rachel Sennett, Michael Rendl
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    TLDR The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.
    The document from 2012 reviews the critical role of mesenchymal-epithelial interactions in hair follicle development and cycling, emphasizing the importance of signaling pathways such as Wnt/ß-catenin, Ectodysplasin (Eda), Bone Morphogenetic Protein (BMP), Fibroblast Growth Factor (Fgf), PDGF, and TGF-beta. It explains how these interactions regulate embryonic hair follicle induction, postnatal hair growth, and adult hair follicle regeneration. The review also discusses the influence of the dermal papilla (DP) in determining hair type and the potential for hair follicle regeneration following wounding in adult mice. It highlights the necessity of a balance between promoting and inhibitory signals for successful hair follicle morphogenesis and cycling, and acknowledges that while significant progress has been made, many details of the underlying mechanisms remain to be elucidated.
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