The Hair Follicle as an Interdisciplinary Model for Biomedical Research: An Eclectic Literature Synthesis

    September 2020 in “ BioEssays ”
    Iain S. Haslam, Ralf Paus
    Studysummary This review discusses recent advancements in hair follicle research and encourages diverse researchers to consider the hair follicle as a model for broader biomedical studies, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 40

    1. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    2. Treatment of Severe Alopecia Areata with Baricitinib JAAD Case Reports · 2019
    3. Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo The EMBO Journal · 2019
    4. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    5. Regeneration of a Bioengineered 3D Integumentary Organ System from iPS Cells Nature protocols · 2019
    6. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    7. Genome-Wide Association Study in Frontal Fibrosing Alopecia Identifies Four Susceptibility Loci Including HLA-B*07:02 Nature Communications · 2019
    8. What’s New in Hair Loss Dermatologic Clinics · 2019
    9. Comparative Effectiveness of Low-Level Laser Therapy for Adult Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Lasers in Medical Science · 2019
    10. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018
    11. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    12. JAK-Inhibitors in Dermatology: Current Evidence and Future Applications Journal of dermatological treatment · 2018
    13. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    14. Ruxolitinib for the Treatment of Severe Alopecia Areata Journal of the American Academy of Dermatology · 2018
    15. Olfactory Receptor OR2AT4 Regulates Human Hair Growth Nature Communications · 2018
    16. JAK Inhibitors for Treatment of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    17. External Light Activates Hair Follicle Stem Cells Through Eyes Via an ipRGC–SCN–Sympathetic Neural Pathway Proceedings of the National Academy of Sciences of the United States of America · 2018
    18. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
    19. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
    20. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    21. Comparison of the Treatment Outcome of Oral Tofacitinib with Other Conventional Therapies in Refractory Alopecia Totalis and Universalis: A Retrospective Study Acta dermato-venereologica · 2018
    22. Low-Level Laser Therapy for the Treatment of Androgenic Alopecia: A Review Lasers in Medical Science · 2017
    23. A Review of Monochromatic Light Devices for the Treatment of Alopecia Areata Lasers in Medical Science · 2017
    24. Epithelial-To-Mesenchymal Stem Cell Transition In A Human Organ: Lessons From Lichen Planopilaris Journal of Investigative Dermatology · 2017
    25. Getting to the Root of Scales, Feathers, and Hair: As Deep as Odontodes? Experimental Dermatology · 2017
    26. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
    27. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    28. N1-Methylspermidine, A Stable Spermidine Analog, Prolongs Anagen And Regulates Epithelial Stem Cell Functions In Human Hair Follicles Archives of dermatological research · 2015
    29. Epithelial–Mesenchymal Transition in Keloid Tissues and TGF-β1–Induced Hair Follicle Outer Root Sheath Keratinocytes Wound repair and regeneration · 2015
    30. Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles Journal of Investigative Dermatology · 2015
    31. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    32. Deadly Hairs, Lethal Feathers: Convergent Evolution of Poisonous Integument in Mammals and Birds Experimental Dermatology · 2014
    33. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    34. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    35. Perivascular Hair Follicle Stem Cells Associate With a Venule Annulus Journal of Investigative Dermatology · 2013
    36. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    37. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    38. Sudden Whitening of the Hair in an 82-Year-Old Woman: The 'Overnight Greying' Phenomenon Clinical and Experimental Dermatology · 2012
    39. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    40. Why Some Women Look Young for Their Age PLOS ONE · 2009

    Related research 8

    1. Optimization of Hair Follicle Spheroids for Hair-On-A-Chip Biomaterials Science · 2024
    2. Skin-On-A-Chip Strategies For Human Hair Follicle Regeneration Experimental Dermatology · 2022
    3. Tissue Engineered Human Hair Follicles from Genetically, Environmentally, and Extrinsically Reprogrammed Dermal Papilla Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    4. Dermal Wnt/β-Catenin Signaling Controls Hair Follicle Dermal Condensate Size During Development Journal of Investigative Dermatology · 2017
    5. Temporary Hair Removal by Low Fluence Photoepilation: Histological Study on Biopsies and Cultured Human Hair Follicles Lasers in surgery and medicine · 2008
    6. Keratins of the Human Hair Follicle International review of cytology · 2005
    7. Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae Experimental Dermatology · 2001
    8. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001