Glutamic Acid-Loaded Separable Microneedle Composite for Long-Acting Hair Regeneration Treatment

    Bricard Mbituyimana, Lina Fu, Hao Wang, Fuyu Qi, Yankai Jiang, Fanbo Meng, Min Wu, Zhijun Shi, Guang Yang
    TLDR Glutamic acid microneedle patches promote better hair growth than traditional treatments.
    The study explores a novel hair regeneration treatment using glutamic acid-loaded biodegradable microneedle (GA-MN) patches, which offer a minimally invasive, long-acting drug delivery system. These patches, tested on male C57BL/6 mice, demonstrated superior hair growth promotion compared to traditional treatments like minoxidil by enhancing vascularization, activating hair follicle stem cells, and extending the anagen phase. The GA-MNs showed effective skin penetration, sustained drug release for up to 45 days, and improved hair follicle proliferation and dermal thickness. The study suggests that GA-MNs could provide a more efficient, self-administered, and less frequent dosing alternative for hair regeneration therapy, with no adverse effects observed in the androgenetic alopecia model.
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