Alopecias in Humans: Biology, Pathomechanisms, and Emerging Therapies

    August 2021 in “ Veterinary dermatology ”
    Anneliese Willems, Rodney Sinclair
    Studysummary This review discusses the biology and pathology of hair growth, exploring novel therapies like sublingual minoxidil and Janus kinase inhibitors, but reports no new clinical data.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 55

    1. Female Pattern Hair Loss: A Comprehensive Review Dermatologic Therapy · 2020
    2. Evaluation of Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia: A Randomized Controlled Trial Journal of The American Academy of Dermatology · 2020
    3. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    4. Oral Minoxidil Improves Background Hair Thickness in Lichen Planopilaris Journal of The American Academy of Dermatology · 2020
    5. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    6. Dihydrotestosterone Regulates Hair Growth Through the Wnt/β-Catenin Pathway in C57BL/6 Mice and In Vitro Organ Culture Frontiers in Pharmacology · 2020
    7. Examining the Safety and Efficacy of Low-Level Laser Therapy for Male and Female Pattern Hair Loss: A Review of the Literature Skin appendage disorders · 2020
    8. Treatment of Severe Alopecia Areata with Baricitinib JAAD Case Reports · 2019
    9. Combination Tofacitinib and Oral Minoxidil Treatment for Severe Alopecia Areata Journal of The American Academy of Dermatology · 2019
    10. The Psychosocial Burden of Alopecia Areata and Androgenetic Alopecia: A Cross-Sectional Multicentre Study Among Dermatological Outpatients in 13 European Countries Journal of the European Academy of Dermatology and Venereology · 2019
    11. A Systematic Review of Outcomes and Patient Satisfaction Following Surgical and Non-Surgical Treatments for Hair Loss Aesthetic Plastic Surgery · 2019
    12. Pathomechanisms of Immune-Mediated Alopecia International Immunology · 2019
    13. Treatment of Alopecia Areata: An Australian Expert Consensus Statement Australasian journal of dermatology · 2018
    14. Feature Characterization of Scarring and Non-Scarring Types of Alopecia by Multiphoton Microscopy Lasers in Surgery and Medicine · 2018
    15. JAK Inhibitors for Treatment of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    16. Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib PubMed · 2018
    17. Female Pattern Hair Loss: A Clinical, Pathophysiologic, and Therapeutic Review International Journal of Women's Dermatology · 2018
    18. Loose Anagen Hair Syndrome: Treatment with Systemic Minoxidil Characterized by Marked Hair Color Change Australasian Journal of Dermatology · 2018
    19. Tofacitinib for the Treatment of Severe Alopecia Areata in Adults and Adolescents Journal of Investigative Dermatology Symposium Proceedings · 2017
    20. An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2017
    21. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    22. Treatment of Chronic Telogen Effluvium with Oral Minoxidil: A Retrospective Study F1000Research · 2017
    23. The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study Journal of Cosmetic Dermatology · 2017
    24. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    25. Prevalence of Hair Shedding Among Women Dermatologic Therapy · 2016
    26. Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss F1000Research · 2015
    27. Treatment of Permanent Chemotherapy-Induced Alopecia with Low Dose Oral Minoxidil Australasian Journal of Dermatology · 2015
    28. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    29. Destruction of the Arrector Pili Muscle and Fat Infiltration in Androgenic Alopecia British Journal of Dermatology · 2014
    30. Primary Cicatricial Alopecia: Diagnosis and Treatment Canadian Medical Association Journal · 2013
    31. Miniaturized Hairs Maintain Contact With the Arrector Pili Muscle in Alopecia Areata but Not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth International Journal of Trichology · 2012
    32. Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss British Journal of Dermatology · 2012
    33. Dissecting the Bulge in Hair Regeneration Journal of Clinical Investigation · 2012
    34. Role of Genetics and Sex Steroid Hormones in Male Androgenetic Alopecia and Female Pattern Hair Loss: An Update Australasian Journal of Dermatology · 2011
    35. Diagnosing and Treating Hair Loss PubMed · 2009
    36. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    37. Cardiovascular Toxicity of Minoxidil in the Marmoset Toxicology Letters · 2008
    38. Androgenetic Alopecia: Clinical Features, Classification, and Treatments Endocrinology and Metabolism Clinics of North America · 2007
    39. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    40. EEMCO Guidance for the Assessment of Hair Shedding and Alopecia Skin Pharmacology and Physiology · 2004
    41. Common Hair Loss Disorders PubMed · 2003
    42. Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls Journal of The European Academy of Dermatology and Venereology · 2003
    43. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    44. Androgenetic Alopecia in Men and Women Clinics in Dermatology · 2001
    45. Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss British Journal of Dermatology · 2001
    46. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    47. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    48. Alopecia Areata: Diagnosis and Management International Journal of Dermatology · 1999
    49. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998
    50. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998
    51. Relationship Between Serum Concentrations, Hemodynamic Effects, and Cardiovascular Lesions in Dogs Treated with Minoxidil Toxicology and Applied Pharmacology · 1996
    52. Hair Anatomy for the Clinician Journal of The American Academy of Dermatology · 1991
    53. Relationship Between Contact Time of Applied Dose and Percutaneous Absorption of Minoxidil From a Topical Solution Journal of Pharmaceutical Sciences · 1990
    54. Whole Body and Regional Hemodynamic Effects of Minoxidil in the Conscious Dog Journal of Cardiovascular Pharmacology · 1984
    55. Cardiac Morphologic Alterations in Acute Minoxidil Cardiotoxicity in Miniature Swine Experimental and Molecular Pathology · 1984

    Related research 7

    1. LB789 Novel IFNγ Aptamer TAGX-0003 Protected Hair Follicles from Immune Privilege Collapse and Reversed Alopecia Areata-Like Phenotype in Humanized Mouse Model ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    2. Androgenetic Alopecia Pattern Hair Regrowth in Patients with Alopecia Areata Treated with Oral JAK Inhibitors Journal of The American Academy of Dermatology · 2020
    3. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    4. Microneedling for the Treatment of Hair Loss Journal of The European Academy of Dermatology and Venereology · 2017
    5. Androgenetic Alopecia and Its Remedies: A Review Journal of drug discovery and therapeutics · 2014
    6. Low-Level Laser Therapy for Treatment of Hair Loss Lasers in Surgery and Medicine · 2013
    7. Topical Minoxidil in Extensive Alopecia Areata, Including 3-Year Follow-Up Dermatology · 1987