Cardiovascular Toxicity of Minoxidil in the Marmoset

August 2008 in “ Toxicology Letters ”

Gilles Hanton, Cécile Sobry, Nicolas Daguès, Gaël Y. Rochefort, Pierre Bonnet, Véronique Eder

TLDR High doses of minoxidil can harm marmoset hearts and kidneys, possibly affecting humans similarly.

The study investigated the cardiovascular toxicity of minoxidil in marmosets. The results showed that high doses of minoxidil caused myocardial necrosis, coronary arteriopathy, and degeneration of renal tubules. The study suggests that minoxidil can have cardiovascular toxicity in marmosets and may have similar effects in humans. The study also found that marmosets are less sensitive than dogs to the cardiotoxicity of minoxidil. Females appear to be slightly more sensitive than males to the adverse effects of minoxidil. The study concluded that echocardiography is a useful method for assessing the effects of minoxidil on heart function.

View this study on sciencedirect.com →

Discuss this study in the Community →

Cited in this study

9 / 9 results

research Relationship Between Serum Concentrations, Hemodynamic Effects, and Cardiovascular Lesions in Dogs Treated with Minoxidil

29 citations , October 1996 in “Toxicology and Applied Pharmacology”

Higher minoxidil doses in dogs cause faster heart rate, lower blood pressure, and heart issues.

1 / 1 results

research Cardiovascular Toxicity of Minoxidil in the Marmoset

15 citations , August 2008 in “Toxicology Letters”

High doses of minoxidil can harm marmoset hearts and kidneys, possibly affecting humans similarly.

Cardiovascular Toxicity of Minoxidil in the Marmoset

Cited in this study

research Relationship Between Serum Concentrations, Hemodynamic Effects, and Cardiovascular Lesions in Dogs Treated with Minoxidil

research Age Dependence of the Cardiac Lesions Induced by Minoxidil in Rats

research The Pharmacologic Basis of the Cardiovascular Toxicity of Minoxidil in the Dog

research Pathogenesis of Cardiovascular Alterations in Dogs Treated with Minoxidil

research A Comparative Study of Minoxidil-Induced Myocardial Lesions in Beagle Dogs and Miniature Swine

research Whole Body and Regional Hemodynamic Effects of Minoxidil in the Conscious Dog

research Minoxidil: Right Atrial Cardiac Pathology in Animals and Humans

research Acute Cardiomyopathy Induced by the Vasodilating Antihypertensive Agent Minoxidil

research Toxicological Studies with the Hypotensive Agent Minoxidil

Related

research Cardiovascular Toxicity of Minoxidil in the Marmoset