Cardiovascular Toxicity of Minoxidil in the Marmoset

August 2008 in “ Toxicology Letters ”

Gilles Hanton, Cécile Sobry, Nicolas Daguès, Gaël Y. Rochefort, Pierre Bonnet, Véronique Eder

minoxidil myocardial necrosis coronary arteriopathy renal tubules degeneration cardiotoxicity echocardiography Rogaine

TLDR High doses of minoxidil can harm marmoset hearts and kidneys, possibly affecting humans similarly.

The study investigated the cardiovascular toxicity of minoxidil in marmosets. The results showed that high doses of minoxidil caused myocardial necrosis, coronary arteriopathy, and degeneration of renal tubules. The study suggests that minoxidil can have cardiovascular toxicity in marmosets and may have similar effects in humans. The study also found that marmosets are less sensitive than dogs to the cardiotoxicity of minoxidil. Females appear to be slightly more sensitive than males to the adverse effects of minoxidil. The study concluded that echocardiography is a useful method for assessing the effects of minoxidil on heart function.

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Research cited in this study

9 / 9 results

research Relationship Between Serum Concentrations, Hemodynamic Effects, and Cardiovascular Lesions in Dogs Treated with Minoxidil

29 citations, October 1996 in “Toxicology and Applied Pharmacology”

Higher minoxidil doses in dogs cause faster heart rate, lower blood pressure, and heart issues.

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research Cardiovascular Toxicity of Minoxidil in the Marmoset

15 citations, August 2008 in “Toxicology Letters”

High doses of minoxidil can harm marmoset hearts and kidneys, possibly affecting humans similarly.

Cardiovascular Toxicity of Minoxidil in the Marmoset

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