Relationship Between Serum Concentrations, Hemodynamic Effects, and Cardiovascular Lesions in Dogs Treated with Minoxidil

October 1996 in “ Toxicology and Applied Pharmacology ”

G. M. Mesfin, Michael J. Higgins, Franklin Robinson, Wei-Zhu Zhong

TLDR Higher minoxidil doses in dogs cause faster heart rate, lower blood pressure, and heart issues.

The study investigated the effects of minoxidil on dogs and found that higher doses resulted in increased heart rate and decreased mean arterial pressure, leading to cardiovascular toxicity. The study established a correlation between serum concentration, hemodynamic effects, and cardiovascular toxicity of minoxidil in dogs. The study suggests that the safety margin of drugs like minoxidil should be based on the ratio of the pharmacokinetically and metabolically adjusted dose/serum concentration of the drug that evokes comparable pharmacologic effects in the animal model and humans.

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research Relationship Between Serum Concentrations, Hemodynamic Effects, and Cardiovascular Lesions in Dogs Treated with Minoxidil

29 citations, October 1996 in “Toxicology and Applied Pharmacology”

Higher minoxidil doses in dogs cause faster heart rate, lower blood pressure, and heart issues.