The Pharmacologic Basis of the Cardiovascular Toxicity of Minoxidil in the Dog

    July 1995 in “ Toxicologic Pathology ”
    G. M. Mesfin, Franklin Robinson, Michael J. Higgins … Donald W. DuCharme
    Studysummary In this study, glyburide prevented or significantly reduced cardiovascular lesions in dogs caused by minoxidil by blocking its hemodynamic effects, suggesting the toxicity is related to these profound effects rather than direct heart toxicity.
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    Research cited in this study 7

    1. Enzymatic and Non-Enzymatic Sulfation Mechanisms in the Biological Actions of Minoxidil Biochemical Pharmacology · 1993
    2. Potassium Channel Openers: Pharmacological and Clinical Aspects Fundamental & Clinical Pharmacology · 1992
    3. Pathogenesis of Cardiovascular Alterations in Dogs Treated with Minoxidil Toxicologic Pathology · 1989
    4. Whole Body and Regional Hemodynamic Effects of Minoxidil in the Conscious Dog Journal of Cardiovascular Pharmacology · 1984
    5. Cardiac Morphologic Alterations in Acute Minoxidil Cardiotoxicity in Miniature Swine Experimental and Molecular Pathology · 1984
    6. Acute Cardiomyopathy Induced by the Vasodilating Antihypertensive Agent Minoxidil Toxicology and Applied Pharmacology · 1979
    7. Toxicological Studies with the Hypotensive Agent Minoxidil Toxicology and Applied Pharmacology · 1977