Veterinary Pharmacology
June 2014
in “
Basic & Clinical Pharmacology & Toxicology
”
TLDR Some plant extracts may treat livestock diseases, certain animal treatments are safe and effective, but more research on drug safety and resistance is needed.
The document from 2014 discusses several studies in the field of veterinary pharmacology. One study showed that alkaloids from Cucumis metuliferus fruit pulp had antiviral activity against IBDV and NDV without toxicity. A meta-analysis indicated potential plant-based treatments for livestock diseases in Bangladesh. A comparison of estrus synchronization treatments in goats favored a shorter 7-day treatment to preserve vaginal flora. Studies also evaluated the immune response to CpG-ODN, the safety of dexamethasone in Wistar rats, the healing effects of ozonized sunflower oil, and the efficacy of a toxin binder in broiler feeds, which was effective against aflatoxin. Ciclosporin was found to be safe in dogs over 60 days, and a study on non-human primates highlighted the need for further research on antimicrobial resistance. Sodium salicylate did not show analgesic effects in sheep, while Enrofloxacin was safe for cats for up to 8 days despite some retinal changes. No difference was found between synthetic and bovine-derived surfactants in treating preterm lambs. A combination drug for veterinary use was safe and effective in broilers. Lastly, a veterinary pharmacovigilance survey in Tamil Nadu, India, reported that over 37% of adverse drug events were related to antimicrobials, antiparasitic, and anti-inflammatory agents, emphasizing the importance of pharmacovigilance programs.