Prenatal Androgenization of Ewes as a Model of Hirsutism in Polycystic Ovary Syndrome

    October 2018 in “ Endocrinology ”
    Joabel Tonellotto dos Santos, Janduí Escarião da Nóbrega, Lady Katerine Serrano Mujica … Fábio Vasconcellos Comim
    Studysummary This study indicates that sheep prenatally androgenized with testosterone show wool fiber diameter changes that parallel the increased hair diameter in women with polycystic ovary syndrome.
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    Research cited in this study 17

    1. Comprehensive Overview of Polycystic Ovary Syndrome Nature Reviews Disease Primers · 2016
    2. Expression of Steroidogenic Enzymes in Human Sebaceous Glands Journal of Endocrinology/Journal of endocrinology · 2014
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    5. An Open Randomized Comparative Study of an Oral Contraceptive Containing Ethinyl Estradiol and Cyproterone Acetate with and without the GnRH Analogue Goserelin in the Long-Term Treatment of Hirsutism Gynecologic and obstetric investigation · 2010
    6. Polycystic Ovary Syndrome: Comprehensive Overview and Diagnostic Criteria The Lancet · 2007
    7. Androgen Excess in Women: Experience with Over 1000 Consecutive Patients The Journal of Clinical Endocrinology and Metabolism · 2004
    8. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003
    9. Comparison of Finasteride Versus Flutamide in the Treatment of Hirsutism European journal of endocrinology · 1999
    10. Comparison of Finasteride and Flutamide in the Treatment of Idiopathic Hirsutism Fertility and Sterility · 1999
    11. Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study The Journal of Clinical Endocrinology and Metabolism · 1998
    12. Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne Journal of Cutaneous Medicine and Surgery · 1998
    13. 5α-Reductase Activity in the Human Hair Follicle Concentrates in the Dermal Papilla Archives of Dermatological Research · 1998
    14. Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque Endocrinology · 1997
    15. Polycystic Ovary Syndrome: Clinical and Biochemical Features New England journal of medicine/˜The œNew England journal of medicine · 1995
    16. The Effects of Finasteride (Proscar) on Hair Growth, Hair Cycle Stage, and Serum Testosterone and Dihydrotestosterone in Adult Male and Female Stumptail Macaques (Macaca Arctoides) The Journal of Clinical Endocrinology and Metabolism · 1994
    17. The Effect of Spironolactone on Hirsutism and Female Androgen Metabolism Clinical endocrinology · 1985

    Related research 1

    1. Comparison of Clinical and Biochemical Markers of Hirsutism in Polycystic Ovary Syndrome: A Study from a Teaching Hospital in Sri Ramachandra Institute, Chennai, India Journal of evolution of medical and dental sciences · 2021