Drug-Induced Scarring And Permanent Alopecia

June 2024 in “ JAAD reviews. ”

Sofia M. Perez, Betty Nguyen, Antonellá Tosti

drug-induced alopecia permanent alopecia chemotherapy drugs taxanes busulfan hedgehog pathway inhibitors tyrosine kinase inhibitors monoclonal antibodies folliculitis decalvans lichen planopilaris

Studysummary In this review, researchers summarize drugs associated with scarring or permanent hair loss, notably after chemotherapy and tyrosine kinase inhibitor treatments, emphasizing the need for stronger evidence and long-term follow-up studies, as current findings are mostly from case reports.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Assessment of Hair Loss and Skin Changes During Treatment in Asian Breast Cancer Patients: A Prospective Cohort Study

1 citations , January 2024 in “The Journal of Dermatology”

In this study, Asian breast cancer patients undergoing taxane-based chemotherapy in the adjuvant treatment group reported significantly increased hair loss, higher melanin index, and more wrinkles compared to other treatments, while most neoadjuvant group patients saw hair loss reversed six months post-surgery.

Persistent Chemotherapy-Induced Alopecia Treated With Low Dose Oral Minoxidil: A Multicenter Retrospective Case Series of 15 Patients

research Persistent Chemotherapy-Induced Alopecia Treated With Low Dose Oral Minoxidil: A Multicenter Retrospective Case Series of 15 Patients

July 2023 in “Dermatology practical & conceptual”

This study reported that low dose oral minoxidil may help treat persistent chemotherapy-induced alopecia, based on a retrospective case series involving 15 patients across multiple centers.

Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report

research Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report

April 2023 in “Heliyon”

This study reports that mesenchymal stromal cell-derived extracellular vesicle injections led to complete hair regrowth in a patient with persistent chemotherapy-induced alopecia.

research Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming?

4 citations , March 2023 in “Current Oncology”

This study reviews current methods and emerging approaches to prevent and treat chemotherapy-induced hair loss, reporting that evidence-based research is needed to validate effective strategies, which could enhance cancer patients’ quality of life and treatment compliance.

research Hair Regrowth in Endocrine Therapy Alopecia With Dutasteride Treatment in Women With Estrogen Positive Breast Cancer

March 2023 in “JAAD case reports”

This paper outlines that treatments reducing estrogen for estrogen receptor-positive breast cancer, such as SERMs and AIs, significantly improve life expectancy but may lead to alopecia in 15% to 25% of patients.

research EGFR Inhibitor-Induced Folliculitis Decalvans: A Case Series and Management Guidelines

7 citations , January 2023 in “Anti-Cancer Drugs”

In this study, researchers reviewed cases of EGFR inhibitor-induced folliculitis decalvans and reported the first known occurrences associated with afatinib in three female NSCLC patients, highlighting the importance of early diagnosis and management to improve patient quality of life.

research Trichoscopic Patterns and Confocal Microscopy Features of Chemotherapy-Induced Alopecia

2 citations , January 2023 in “Skin Appendage Disorders”

In this study, chemotherapy-induced alopecia in cancer patients showed specific trichoscopic patterns and abnormal hair shaft morphology, suggesting intermittent follicle damage from chemotherapy, but larger studies are needed for confirmation.

research Efficacy of Low-Dose Oral Minoxidil in the Management of Anticancer Therapy-Induced Alopecia in Patients With Breast Cancer: A Retrospective Cohort Study

December 2022 in “Journal of The American Academy of Dermatology”

This letter highlights the lack of evidence on managing persistent alopecia induced by chemotherapy and endocrine therapy in breast cancer patients, noting that prior studies have not included endocrine therapy-induced alopecia.

research Permanent Chemotherapy-Induced Alopecia After Hematopoietic Stem Cell Transplantation Treated With Low-Dose Oral Minoxidil

4 citations , February 2022 in “JAAD case reports”

This case report describes a patient with permanent chemotherapy-induced alopecia who experienced full hair regrowth after treatment with low-dose oral minoxidil.

Clinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors

research Clinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors

10 citations , September 2021 in “JAMA Dermatology”

This study reports that persistent chemotherapy-induced alopecia in breast cancer patients frequently resembles androgenetic alopecia, and treatment with minoxidil, alone or with antiandrogens, improved hair density in many cases.

research Peroxisome Proliferator-Activated Receptor-γ Signalling Protects Hair Follicle Stem Cells from Chemotherapy-Induced Apoptosis and Epithelial-Mesenchymal Transition

19 citations , September 2021 in “British journal of dermatology/British journal of dermatology, Supplement”

This study suggests that pretreatment with a PPAR-γ modulator may prevent damage to hair follicle stem cells caused by a chemotherapy metabolite, potentially offering a strategy to mitigate permanent chemotherapy-induced alopecia.

research Permanent Alopecia in Breast Cancer Patients: Role of Taxanes and Endocrine Therapies

2 citations , March 2021 in “Cutis”

This article highlights that permanent chemotherapy-induced alopecia can occur and is more commonly associated with taxane therapy, advising awareness among patients and clinicians.

research Imatinib-Induced Classical Lichen Planopilaris in Blaschko-Linear Distribution Leading to Cicatricial Alopecia

2 citations , February 2021 in “Indian Dermatology Online Journal”

This case report describes the first instance of classical lichen planopilaris with atrophic lichenoid plaques developing in a Blaschko-linear pattern due to imatinib treatment in a patient with chronic myeloid leukemia.

research Erosive Pustular Dermatosis of the Scalp Induced by Gefitinib: Case and Review of the Literature

5 citations , January 2021 in “Dermatology Online Journal”

This case report describes erosive pustular dermatosis of the scalp in a patient undergoing gefitinib treatment for lung cancer, and reviews literature on drug-induced cases of this rare condition.

research Erosive Pustular Dermatosis of the Scalp: Causes and Treatments

13 citations , June 2020 in “International Journal of Dermatology”

This review discusses erosive pustular dermatosis of the scalp, highlighting its wide variety of causes and multiple effective treatment options beyond high-potency topical steroids, and reports no new clinical results.

Impact of a Topical Lotion, CG428, on Permanent Chemotherapy-Induced Alopecia in Breast Cancer Survivors: A Pilot Randomized Double-Blind Controlled Clinical Trial (VOLUME RCT)

research Impact of a Topical Lotion, CG428, on Permanent Chemotherapy-Induced Alopecia in Breast Cancer Survivors: A Pilot Randomized Double-Blind Controlled Clinical Trial (VOLUME RCT)

3 citations , July 2019 in “Supportive Care in Cancer”

The lotion CG428 did not show effectiveness in treating permanent hair loss in breast cancer survivors.

research Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia

43 citations , March 2019 in “JAMA Dermatology”

This study found that persistent chemotherapy-induced alopecia is often more severe and diffuse than alopecia from endocrine therapy, with both conditions negatively impacting patients' emotional wellbeing, and moderate to significant improvement was observed with dermatologic therapy.

research Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study

59 citations , August 2018 in “The oncologist”

This study found that permanent chemotherapy-induced alopecia was relatively common three years after treatment among breast cancer patients receiving adjuvant chemotherapy, particularly those on taxane-based regimens.

Persistent Alopecia in a Breast Cancer Patient Following Taxane Chemotherapy and Adjuvant Endocrine Therapy: Case Report and Review of Post-treatment Hair Loss in Oncology Patients with Breast Cancer

research Persistent Alopecia in a Breast Cancer Patient Following Taxane Chemotherapy and Adjuvant Endocrine Therapy: Case Report and Review of Post-treatment Hair Loss in Oncology Patients with Breast Cancer

3 citations , July 2018 in “Cureus”

This case study reports that a woman with breast cancer experienced persistent alopecia after taxane chemotherapy and endocrine therapy, and significant improvement was seen with topical minoxidil.

research Monitoring Chemotherapy-Induced Alopecia With Trichoscopy

23 citations , July 2018 in “Journal of Cosmetic Dermatology”

This study describes a distinct pattern of trichoscopic features associated with chemotherapy-induced alopecia and how these features evolve through different phases of chemotherapy treatment.

Persistent Major Alopecia Following Adjuvant Docetaxel for Breast Cancer: Incidence, Characteristics, and Prevention with Scalp Cooling

research Persistent Major Alopecia Following Adjuvant Docetaxel for Breast Cancer: Incidence, Characteristics, and Prevention with Scalp Cooling

19 citations , June 2018 in “Breast Cancer Research and Treatment”

This study found that adjuvant docetaxel treatment for breast cancer at cumulative doses of 400 mg/m² or higher is associated with a 10% prevalence of persistent alopecia leading to wig use, but this was completely prevented with scalp cooling.

research Endocrine Therapy-Induced Alopecia in Patients With Breast Cancer

67 citations , April 2018 in “JAMA Dermatology”

This study found that endocrine therapy for breast cancer is associated with a pattern of hair loss similar to androgenetic alopecia, negatively impacting quality of life despite mild severity.

research Minoxidil for Endocrine Therapy–Induced Alopecia in Women With Breast Cancer—Saint Agatha’s Blessing?

9 citations , April 2018 in “JAMA Dermatology”

This abstract provided no research findings as it contains only website navigation and service information.

research Trichoscopic Findings of Erosive Pustular Dermatosis of the Scalp Associated with Gefitinib

21 citations , June 2017 in “Case Reports in Dermatology”

This case report describes a 57-year-old Japanese female who developed scarring alopecia linked to gefitinib, an EGFR inhibitor, with improvement in hair loss after reducing the drug dosage.

research Permanent Diffuse Alopecia After Hematopoietic Stem Cell Transplantation in Childhood

16 citations , March 2017 in “Bone Marrow Transplantation”

In this study, permanent alopecia after haematopoietic stem cell transplantation was found in 16% of patients and was significantly associated with conditioning regimens involving busulphan.

Permanent Alopecia in Patients with Breast Cancer After Taxane Chemotherapy and Adjuvant Hormonal Therapy: Clinicopathologic Findings in a Cohort of 10 Patients

research Permanent Alopecia in Patients with Breast Cancer After Taxane Chemotherapy and Adjuvant Hormonal Therapy: Clinicopathologic Findings in a Cohort of 10 Patients

31 citations , March 2017 in “Journal of The American Academy of Dermatology”

This study observed various patterns of permanent alopecia in breast cancer patients treated with taxanes and adjuvant hormonal chemotherapy, hypothesizing disruptions in hair follicle cycles due to chemoinflammatory and hormonal factors.

Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn’s Disease: Dramatic Improvement After Drug Discontinuation and Treatment with Adjuvant Systemic and Topical Therapies

research Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn’s Disease: Dramatic Improvement After Drug Discontinuation and Treatment with Adjuvant Systemic and Topical Therapies

19 citations , November 2016 in “Dermatology and therapy”

This study describes a case where stopping infliximab and using oral minocycline with topical treatments effectively resolved alopecia and scalp psoriasis in a woman with Crohn's disease.

research Clinical and Histological Study of Permanent Alopecia After Bone Marrow Transplantation

23 citations , December 2015 in “Anais Brasileiros de Dermatologia”

This study identified two distinct histological patterns in permanent alopecia following bone marrow transplantation, suggesting links to myeloablative chemotherapy and chronic graft-versus-host disease.

research Unique Cutaneous Reaction to Second- and Third-Generation Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia

32 citations , September 2015 in “Dermatology”

This study describes a newly recognized skin reaction associated with dasatinib, nilotinib, and ponatinib, marked by a lichenoid exanthem with severe pruritus that may necessitate discontinuation of therapy.

research Treatment of Permanent Chemotherapy-Induced Alopecia with Low Dose Oral Minoxidil

36 citations , May 2015 in “Australasian Journal of Dermatology”

This case report described cosmetically significant hair regrowth in a 39-year-old woman with permanent chemotherapy-induced alopecia after continuous oral minoxidil use.

research Permanent Chemotherapy-Induced Nonscarring Alopecia and Premature Ovarian Failure

5 citations , March 2015 in “Clinical and Experimental Dermatology”

This case report describes a 22-year-old woman who developed persistent, non-scarring hair loss and premature ovarian failure following a myeloablative umbilical cord transplant for acute myeloid leukemia.

research Hair Loss and Hedgehog Inhibitors: A Class Effect?

9 citations , December 2014 in “British Journal of Dermatology”

This letter discusses potential hair loss effects of Hedgehog inhibitors but presents no new clinical findings, urging further exploration of this possible class effect.

research Aromatase Inhibitor Therapy and Hair Loss Among Breast Cancer Survivors

34 citations , November 2013 in “Breast Cancer Research and Treatment”

This study found that female breast cancer survivors using aromatase inhibitors were observed to have a higher likelihood of experiencing hair loss and thinning compared to those not treated with these drugs.

research Alopecia With Endocrine Therapies in Patients With Cancer

48 citations , September 2013 in “Oncologist”

This study reported that alopecia is a common but often underreported side effect of endocrine-based cancer therapies, with tamoxifen showing the highest incidence of hair loss among analyzed treatments.

research Severe Refractory Scarring Alopecia Associated With Combinational Use of Ficlatuzumab (AV-299) and Gefitinib

6 citations , May 2013 in “Journal of Clinical Oncology”

Combining Ficlatuzumab and Gefitinib can cause severe hair loss.

research Docetaxel and Permanent Alopecia

8 citations , April 2013 in “Journal of The American Academy of Dermatology”

This correspondence comments on the unknown prevalence of permanent alopecia following high-dose docetaxel chemotherapy and highlights the need for further understanding and prevention strategies.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , January 2013 in “The Lancet Oncology”

This review discusses the pathobiology of chemotherapy-induced alopecia and highlights challenges in managing it, reporting no new clinical results and emphasizing the need for well-designed preclinical models to develop effective treatments.

research Radiation- and Chemotherapy-Induced Permanent Alopecia: Case Series

14 citations , January 2013 in “Journal of Cutaneous Medicine and Surgery”

This study describes permanent scalp alopecia in patients receiving chemotherapy, radiation, or both, and highlights the need for further research to identify causative factors and mitigation strategies.

Permanent Scalp Alopecia Related to Breast Cancer Chemotherapy by Sequential Fluorouracil/Epirubicin/Cyclophosphamide (FEC) and Docetaxel: A Prospective Study of 20 Patients

research Permanent Scalp Alopecia Related to Breast Cancer Chemotherapy by Sequential Fluorouracil/Epirubicin/Cyclophosphamide (FEC) and Docetaxel: A Prospective Study of 20 Patients

68 citations , May 2012 in “Annals of Oncology”

This study reports that permanent and severe alopecia is a newly identified complication of the FEC 100–docetaxel regimen used for adjuvant breast cancer treatment.

research Erosive Pustular Dermatosis of the Scalp-Like Eruption Due to Gefitinib: Case Report and Review of Alopecia Associated with EGFR Inhibitors

36 citations , January 2012 in “Dermatology”

This case report describes how discontinuing the EGFR inhibitor gefitinib led to rapid improvement of erosive scalp pustules in a woman with non-small-cell lung cancer, despite previous antibiotic and steroid treatment failures.

research Scarring Alopecia Associated With the Epidermal Growth Factor Receptor Inhibitor Erlotinib

32 citations , April 2011 in “Journal of the American Academy of Dermatology”

Erlotinib may cause scarring hair loss.

research Permanent Alopecia After Systemic Chemotherapy: A Clinicopathological Study of 10 Cases

57 citations , March 2011 in “The American Journal of Dermatopathology”

This study found that permanent alopecia can occur after certain chemotherapy treatments and presents as nonscarring hair loss similar to androgenetic alopecia, with specific histological features that could be misdiagnosed without proper clinicopathological correlation.

research A Case of Cicatricial Alopecia Associated with Erlotinib

25 citations , January 2011 in “Annals of Dermatology”

This case report documents a 61-year-old woman treated with erlotinib who experienced the rare side effect of cicatricial alopecia.

research Permanent Chemotherapy-Induced Alopecia: Case Report and Review of the Literature

67 citations , May 2010 in “Journal of The American Academy of Dermatology”

This article discusses a unique case of permanent chemotherapy-induced alopecia in a patient receiving chemotherapy for breast cancer, characterized by a distinctive histologic finding and excludes bone marrow transplantation, but reports no new clinical results.

research Folliculitis Decalvans Associated with Erlotinib

25 citations , April 2010 in “Clinical and Experimental Dermatology”

Erlotinib can cause hair loss and scalp issues, which improve after stopping the drug.

research Irreversible And Severe Alopecia Following Docetaxel Or Paclitaxel Cytotoxic Therapy For Breast Cancer

61 citations , April 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

This study found that irreversible and severe alopecia can occur following docetaxel or paclitaxel chemotherapy in breast cancer patients.

research Onset of Lichen Planopilaris During Treatment with Etanercept

39 citations , March 2008 in “British Journal of Dermatology”

This study documented the onset of lichen planopilaris during treatment with etanercept.

research Six Cases of Permanent Alopecia After Various Conditioning Regimens Commonly Used in Hematopoietic Stem Cell Transplantation

40 citations , September 2007 in “Bone marrow transplantation”

Certain chemotherapy drugs can cause permanent hair loss in stem cell transplant patients.

research Primary Cicatricial Alopecias: Clinicopathology of 112 Cases

254 citations , December 2003 in “Journal of the American Academy of Dermatology”

This study reviewed the epidemiology and treatment of inflammatory cicatricial alopecias and highlighted the importance of scalp biopsies for accurate diagnosis in a mixed ethnic population at a university hair clinic.

research Tamoxifen-Induced Total Alopecia

19 citations , June 2001 in “Annals of Internal Medicine”

This case report describes total alopecia in a 53-year-old woman after 13 months of tamoxifen treatment for breast cancer, with normal hair distribution maintained elsewhere.

research Permanent Alopecia Following Chemotherapy and Bone Marrow Transplantation

63 citations , May 2000 in “Australasian Journal of Dermatology”

This case study reported a 23-year-old woman with chronic myeloid leukemia who developed permanent hair loss after chemotherapy and did not respond to topical minoxidil treatment.