Trichoscopic Findings of Erosive Pustular Dermatosis of the Scalp Associated with Gefitinib

    June 2017 in “ Case Reports in Dermatology ”
    Tomohisa Fukui, Hideo Kitamura, Ken Harada, Hajime Nakano, Daisuke Sawamura
    TLDR Reducing gefitinib dosage improved hair loss, but scarring remained.
    The document described a case of a 57-year-old Japanese female who developed scarring alopecia linked to gefitinib, an EGFR inhibitor for non-small cell lung cancer. The patient experienced hair loss and scalp lesions similar to erosive pustular dermatosis of the scalp (EPDS) after starting gefitinib. Trichoscopy showed follicular keratotic plugging and absence of follicular openings, indicating scarring alopecia. Treatment with oral minocycline and topical steroids was ineffective until the gefitinib dosage was reduced, which led to partial hair regrowth but left scars. The study emphasized the need for early diagnosis and management of EGFR inhibitor-associated alopecia to prevent scarring.
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