Impact of a Topical Lotion, CG428, on Permanent Chemotherapy-Induced Alopecia in Breast Cancer Survivors: A Pilot Randomized Double-Blind Controlled Clinical Trial (VOLUME RCT)

July 2019 in “ Supportive Care in Cancer ”

Danbee Kang, Im Ryung Kim, Yeon Hee Park, Young Hyuck Im, Di Zhao, Eliseo Güallar, Jin Seok Ahn, Juhee Cho

TLDR The lotion CG428 did not show effectiveness in treating permanent hair loss in breast cancer survivors.

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research Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study

59 citations , August 2018 in “The oncologist”

Some breast cancer patients still experience hair loss three years after chemotherapy, especially with taxane-based treatments.

research A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention

38 citations , September 2017 in “Oncologist”

Scalp cooling can help prevent chemotherapy-induced hair loss with a 50-90% success rate and is safe for patients.

research Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

29 citations , August 2015 in “Journal of Investigative Dermatology”

Cyclosporine A promotes hair growth and prolongs the active growth phase in human hair follicles, but may work differently than in rodents.

research Long-Term Safety and Efficacy of Bimatoprost Solution 0.03% Application to the Eyelid Margin for the Treatment of Idiopathic and Chemotherapy-Induced Eyelash Hypotrichosis: A Randomized Controlled Trial

38 citations , March 2015 in “British journal of dermatology/British journal of dermatology, Supplement”

Bimatoprost solution is effective and safe for long-term use in treating eyelash thinning.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , February 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

research Permanent Scalp Alopecia Related to Breast Cancer Chemotherapy by Sequential Fluorouracil/Epirubicin/Cyclophosphamide (FEC) and Docetaxel: A Prospective Study of 20 Patients

68 citations , November 2012 in “Annals of Oncology”

Some breast cancer chemotherapy can cause permanent hair loss.

research Prevention of Chemotherapy-Induced Alopecia in Rodent Models

27 citations , March 2008 in “Cell stress & chaperones”

Localized heat or specific injections can prevent chemotherapy-induced hair loss without affecting cancer treatment.

research A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia

127 citations , July 1996 in “Journal of The American Academy of Dermatology”

Minoxidil shortens baldness from chemotherapy by 50.2 days without significant side effects.