research Tfap2b Specifies an Embryonic Melanocyte Stem Cell That Retains Adult Multi-Fate Potential
The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.
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research Worldwide Cancer Incidences Analyzed by Sex, Age, and Skin Type Over Time (1955-2007), Excluding Skin Cancer, Reveals Important Carcinogenic Drivers
Cancer rates are increasing in developed countries, with estrogen, aging, low vitamin D3, and HPV infection as common causes.
research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice
Overexpressing SSAT enzyme reduces prostate tumor growth in mice.
research Viremia and Viruria of Trichodysplasia Spinulosa-Associated Polyomavirus Before the Development of Clinical Disease in a Kidney Transplant Recipient
The virus linked to a rare disease was found in a patient's blood and urine before skin symptoms appeared.
research Processed Radish Extract Melanogenesis in Humans and Induces Anti-Photoaging Effects in Ultraviolet B-Induced Hairless Mouse Model
Heated radish extract may help lighten skin and reduce aging signs.
research Hair Growth Promoting Effect of Radish Crude Saponin Extract on Athymic Nude Mice
Radish saponin extract may help grow hair in balding mice.
research Spermidine/Spermine-N1-Acetyltransferase: A Key Metabolic Regulator
SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.
research ERG Induces Androgen Receptor-Mediated Regulation of SOX9 in Prostate Cancer
ERG increases SOX9, promoting prostate cancer growth and invasion.
research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter
The system allows precise control of gene expression in mouse skin, useful for studying skin biology.
research The Malignant Capacity of Skin Tumors Induced by Expression of a Mutant H-Ras Transgene Depends on the Cell Type Targeted
The risk of skin tumors becoming malignant depends on the specific skin cell type affected.
research Cytochrome P450: A Target for Drug Development for Skin Diseases
Modulating Cytochrome P450 activity could help develop new skin disease treatments.
research Development of Heritable Melanoma in Transgenic Mice
The transgene likely activated an oncogene or interrupted a tumor suppressor gene, causing melanoma in mice.
research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis
Notch signaling is essential for healthy skin and hair follicle maintenance.
research Do Changes in Chromosomes Cause Aging?
Chromosomal changes, including those in the WRN gene and rDNA, may significantly contribute to aging.
research Skin-Specific Expression of a Truncated E1a Oncoprotein Binding to p105-Rb Leads to Abnormal Hair Follicle Maturation Without Increased Epidermal Proliferation
The oncoprotein causes abnormal hair growth without increasing skin cancer risk.
research Triclocarban, Triclosan, Bromochlorophene, Chlorophene, and Climbazole Effects on Nuclear Receptors: An In Silico and In Vitro Study
Five preservatives may disrupt hormone function and need more health and environmental risk assessment.
research Genetically Modified Laboratory Mice with Sebaceous Glands Abnormalities
Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.
research Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression
The KRTAP11-1 gene promoter is crucial for specific expression in sheep wool cortex.
research Targeted Knockout of Beta-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects
Removing β-catenin in certain stem cells causes hair whitening and pigmentation issues.
research Poly(rC) Binding Protein 2 Acts as a Negative Regulator of IRES-Mediated Translation of Hr mRNA
A protein called PCBP2 controls the production of a hair growth protein by interacting with its genetic message and is linked to hair loss when this control is disrupted.
research Isotretinoin Treatment Upregulates the Expression of P53 in the Skin and Sebaceous Glands of Patients with Acne Vulgaris
Acne treatment with isotretinoin increases the presence of p53, a protein, in skin and oil glands, which may help reduce acne severity.
research Signal Integrator Function of CXXC5 in Cancer
CXXC5 can both suppress and promote cancer, making it a complex target for treatment.
research Dermal Papilla Cells: From Basic Research to Translational Applications
Dermal papilla cells can help regrow hair and are promising for hair loss treatments.
research Effects of Nannochloropsis Salina Fermented Oil on Proliferation of Human Dermal Papilla Cells and Hair Growth
Nannochloropsis salina fermented oil may help treat hair loss by promoting hair growth and reducing oxidative stress.
research Effects of the Complex of Panicum Miliaceum Extract and Triticum Aestivum Extract on Hair Condition
Millet and wheat extracts may improve hair health and promote growth.
research Bioengineered Skin Organoids: From Development to Applications
Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.
research A Bio-Functional Wnt3a Gradient Microarray for Cell Niche Studies
The study created a tool that mimics natural cell signals, which increased cell growth and could help with hair regeneration research.