Viremia and Viruria of Trichodysplasia Spinulosa-Associated Polyomavirus Before the Development of Clinical Disease in a Kidney Transplant Recipient
June 2019
in “
Transplant infectious disease
”
TLDR The virus linked to a rare disease was found in a patient's blood and urine before skin symptoms appeared.
The case report described a 65-year-old woman who developed trichodysplasia spinulosa (TS) six months after a kidney transplant while on immunosuppressive therapy. She presented with facial follicular papules, skin thickening, and eyebrow alopecia, leading to a leonine appearance. A skin biopsy confirmed the presence of Trichodysplasia Polyomavirus (TSPyV) DNA. Her immunosuppressive regimen was adjusted, and treatments including intravenous cidofovir and leflunomide were administered, resulting in improved skin lesions and cosmetic appearance. However, she experienced three episodes of graft rejection and eventual renal failure. Retrospective analysis revealed TSPyV DNA in blood and urine samples two months before clinical symptoms, highlighting the potential for early detection of TS.
