Leflunomide for the Treatment of Trichodysplasia Spinulosa in a Liver Transplant Recipient
March 2017
in “
Transplant Infectious Disease
”
leflunomide trichodysplasia spinulosa trichodysplasia spinulosa-associated polyomavirus immunosuppressive therapy spiny follicular papules hyperkeratotic material hair follicles topical agents oral valganciclovir TS polyomavirus immunosuppressants papules keratin follicles topical treatments valganciclovir
TLDR Leflunomide successfully treated a rare skin condition in a liver transplant patient.
The document reported a case of trichodysplasia spinulosa (TS), a rare dermatologic condition linked to immunosuppressive therapy in solid organ transplant recipients, characterized by spiny follicular papules on various body parts. The condition is caused by the trichodysplasia spinulosa-associated polyomavirus. Traditional treatments included reducing immunosuppression, topical agents like cidofovir or retinoids, and oral valganciclovir. This case highlighted the successful treatment of generalized TS with leflunomide in a liver transplant recipient.
