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Glossary Trichodysplasia Spinulosa

rare skin condition with spiny papules in immunocompromised individuals

Trichodysplasia Spinulosa is a rare skin condition often seen in immunocompromised individuals, such as organ transplant recipients. It is characterized by the development of spiny, follicular papules primarily on the face, and is caused by the Trichodysplasia spinulosa-associated polyomavirus (TSPyV). This condition can lead to significant cosmetic concerns and may require antiviral or immunosuppressive treatment adjustments.

Research

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research Viral-associated trichodysplasia spinulosa: a case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus

71 citations , January 2011 in “Journal of cutaneous pathology”

This case report describes the first confirmed instance of trichodysplasia spinulosa in a child with Down syndrome and leukemia, linking it to the TS-associated polyomavirus.

research Trichodysplasia spinulosa associated with chemotherapy for acute lymphocytic leukaemia

55 citations , May 2007 in “Australasian journal of dermatology”

This case report describes the characteristic clinicopathological features of trichodysplasia spinulosa in two boys with acute lymphocytic leukemia, highlighting its resolution as immune function normalizes.

research Leflunomide for the treatment of trichodysplasia spinulosa in a liver transplant recipient

22 citations , March 2017 in “Transplant Infectious Disease”

This case report describes successful treatment of generalized trichodysplasia spinulosa with leflunomide in a patient undergoing immunosuppressive therapy following solid organ transplantation.

research Trichodysplasia spinulosa: a polyomavirus infection specifically targeting follicular keratinocytes in immunocompromised patients

19 citations , March 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, evidence that trichodysplasia spinulosa-associated polyomavirus targets follicular keratinocytes was observed in a pediatric case, suggesting these cells as the primary viral target.

research Trichodysplasia Spinulosa: Rare Presentation of Polyomavirus Infection in Immunocompromised Patients

12 citations , November 2014 in “Journal of Cutaneous Medicine and Surgery”

This report describes a case where oral valganciclovir treatment led to improved skin texture and hair regrowth in a patient with trichodysplasia spinulosa.

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