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This case report describes the first confirmed instance of trichodysplasia spinulosa in a child with Down syndrome and leukemia, linking it to the TS-associated polyomavirus.

In this case study, a rare viral infection called trichodysplasia spinulosa was diagnosed in a 10-year-old girl post-kidney transplant; she was treated successfully with reduced immunosuppression alongside leflunomide and valganciclovir, though the efficacy of valganciclovir remains uncertain.

This case study reported TSPyV DNA detection in blood and urine samples before trichodysplasia spinulosa skin lesions developed in a kidney transplant patient under immunosuppressive therapy.

This review examines trichodysplasia spinulosa, a rare virus-linked skin condition in immunosuppressed individuals, noting its clinical features and highlighting antiviral treatment efficacy, without new clinical results.

This report highlights hyperpigmentation as an underreported side effect of topical cidofovir treatment for trichodysplasia spinulosa.