Effects of the Complex of Panicum Miliaceum Extract and Triticum Aestivum Extract on Hair Condition

October 2023 in “ Nutrients ”

Nahyun Choi, Ki Cheon Kim, Pan-Young Jeong, Bumsik Kim

Panicum miliaceum extract Triticum aestivum extract MWC human dermal papilla cells iDPCs anagen phase antioxidant enzymes growth factors hair growth-related genes inflammatory cytokines wnt/β-catenin signaling pathway dihydrotestosterone DHT millet extract wheat extract hair growth hair health antioxidative anti-inflammatory

TLDR Millet and wheat extracts may improve hair health and promote growth.

The study investigated the effects of a complex of Panicum miliaceum (millet) and Triticum aestivum (wheat) extracts (MWC) on hair health using human dermal papilla cells (iDPCs) and an anagen-synchronized mouse model. MWC treatment increased mRNA levels of antioxidant enzymes, growth factors, and hair growth-related genes while reducing inflammatory cytokine mRNA levels in vitro. In vivo, MWC administration promoted hair growth by elongating the anagen phase and enhancing the expression of growth factors via the wnt/β-catenin signaling pathway. Importantly, MWC did not affect dihydrotestosterone (DHT) levels, suggesting it does not cause hormone imbalance. These findings suggest that MWC could be a potential treatment for improving hair health through antioxidative, anti-inflammatory, and hair growth-promoting actions without adverse side effects.

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