TLDR The study created a tool that mimics natural cell signals, which increased cell growth and could help with hair regeneration research.
The study engineered a bio-functional Wnt3a gradient microarray using multiphoton microfabrication and micropatterning technology to investigate its effects on human hair dermal papilla cells (HHDPCs). The Wnt3a gradient, created by immobilizing biotinylated Wnt3a (bWnt3a) on a neutravidin gradient, successfully activated the Wnt/β-catenin signaling pathway, leading to increased cell proliferation and fibronectin deposition in a dose-dependent manner. The findings indicate that the engineered Wnt3a niche can sustain the hair-inductive phenotype of HHDPCs, making it a valuable in vitro model for studying Wnt signaling and its effects on cell behavior, potentially aiding in hair regeneration research and drug screening.
13 citations,
April 2020 in “Experimental Cell Research” PCAT1 helps hair growth by controlling miR-329/Wnt10b.
42 citations,
January 2017 in “Stem cells international” Adding hyaluronic acid helps create larger artificial hair follicles in the lab.
9 citations,
August 2015 in “Tissue Engineering and Regenerative Medicine” Human skin cell byproducts can potentially be used to treat hair loss and promote hair growth.
85 citations,
April 2012 in “PLOS ONE” Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.
88 citations,
February 2011 in “Journal of Dermatological Science” Minoxidil helps hair growth by activating the β-catenin pathway.
321 citations,
December 2009 in “Journal of Dermatological Science” Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
149 citations,
April 2004 in “Journal of Dermatological Science” Minoxidil boosts hair growth by increasing cell production and survival.
April 2023 in “Advanced functional materials” The study created a tool that mimics natural cell signals, which increased cell growth and could help with hair regeneration research.
