TLDR The study created a tool that mimics natural cell signals, which increased cell growth and could help with hair regeneration research.
The study engineered a bio-functional Wnt3a gradient microarray using multiphoton microfabrication and micropatterning technology to investigate its effects on human hair dermal papilla cells (HHDPCs). The Wnt3a gradient, created by immobilizing biotinylated Wnt3a (bWnt3a) on a neutravidin gradient, successfully activated the Wnt/β-catenin signaling pathway, leading to increased cell proliferation and fibronectin deposition in a dose-dependent manner. The findings indicate that the engineered Wnt3a niche can sustain the hair-inductive phenotype of HHDPCs, making it a valuable in vitro model for studying Wnt signaling and its effects on cell behavior, potentially aiding in hair regeneration research and drug screening.
Cited in this study
7 / 7 results
13 citations
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April 2023 in “Advanced functional materials” The study created a tool that mimics natural cell signals, which increased cell growth and could help with hair regeneration research.
