Processed Radish Extract Melanogenesis in Humans and Induces Anti-Photoaging Effects in Ultraviolet B-Induced Hairless Mouse Model

The study demonstrated that Heated Radish Extract (HRE) effectively suppressed tyrosinase activity and melanin production in B16/F10 melanoma cells and reduced the expression of melanin production pathway components. In UVB-exposed hairless mice, HRE inhibited MMP expression, reduced wrinkle formation, and prevented collagen degradation. Additionally, a 3% HRE cream improved skin resilience, moisture, and tone in human skin. These findings suggested that HRE could be a potent skin whitening and anti-aging product.