Hair Growth Promoting Effect of Radish Crude Saponin Extract on Athymic Nude Mice
March 2019
in “
The International Journal of Advanced Smart Convergence
”
radish saponin hair growth topical application follicular keratin differentiation hair density hair follicles BrdU-labeled keratinocytes anagen follicle epidermal keratinocyte proliferation alopecia radish extract hair restoration topical treatment keratin repair hair thickness hair roots BrdU cells growth phase follicle skin cell growth hair loss
TLDR Radish saponin extract may help grow hair in balding mice.
The study conducted five years ago investigated the hair restoration efficacy of radish saponin extracts on nude mice, which are genetically predisposed to pattern balding. The results showed that the topical application of radish saponin stimulated hair growth in these mice by repairing the follicular keratin differentiation defect. The hair density of the treated mice significantly increased compared to the control group. Histological observation revealed that the treatment groups had fully formed hair follicles, with the number of hair follicles being up to three times higher than that of the control group. Furthermore, the number of BrdU-labeled keratinocytes per anagen follicle and the number of BrdU-labeled epidermal keratinocyte proliferation significantly increased in the treated mice compared to the control mice. This suggests that radish saponin could be a potential strategy for managing certain forms of alopecia.
