September 2024 in “Journal of the American Academy of Dermatology” Generic topical and transdermal systems usually cause minimal irritation or sensitization.
July 2025 in “Archives of Toxicology” The study introduced an advanced skin model, ImmuSkin-MT, which effectively distinguished between different strengths of skin sensitizers by mimicking the interaction of immune cells in skin tissue.
February 2025 in “Journal of Cosmetic Dermatology” This study examined the sensitization potential of common hair care products and found that certain ingredients, like cobalt chloride and nickel sulfate, frequently cause allergic reactions in individuals with hair diseases, providing essential insights for personalized treatment strategies.
1 citations
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November 2023 in “Contact dermatitis” In this study, sensitization to ethylhexyl salicylate was found in 27.3% of patients with frontal fibrosing alopecia, suggesting it may be a potential contact allergen for this condition.
16 citations
,
December 2012 in “The Clinical Journal of Pain” This study found that trichodynia is associated with both peripheral and central sensitization, potentially linked to hair cycle abnormalities and chronic pain through proinflammatory agents.
1 citations
,
June 2023 in “Biomolecules & therapeutics” This article reviews the role of nitric oxide in skin health, including its influence on immune responses and potential therapeutic applications for contact dermatitis, but reports no new clinical results.
January 2026 in “Derecho y cambio social.” This narrative review found that fragrances and isothiazolinone preservatives in deodorants are key contributors to skin sensitization, while magnesium hydroxide shows promise as a less irritating alternative for managing body odor without blocking sweat ducts.
December 2025 in “Applied and Computational Engineering” In this study, researchers explored the potential allergenicity and harmful effects of hair dyes, noting that adverse effects such as sensitization and potential carcinogenicity are not inevitable and can vary based on individual physiological differences.
1 citations
,
February 2025 in “Journal of Pharma Insights and Research.” This analysis explores the potential benefits of various nutraceuticals, such as Ashwagandha, Cinnamon, and Fenugreek, in managing Polycystic Ovarian Disease, suggesting these may improve menstrual regularity, insulin sensitivity, and other symptoms when used alongside conventional treatments.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that a skincare product effectively prevented and reduced pollen allergen accumulation in hair follicle models by forming a protective film and exhibiting strong cleansing properties, suggesting its potential to protect skin from environmental elements that can lead to irritation and allergic reactions.
In this review, the researchers highlighted the prevalence of allergens in hair cosmetics and stressed the importance of patch testing to identify allergic contact dermatitis, discussing potential treatments when allergen avoidance isn't possible.
21 citations
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May 2014 in “Toxicological Sciences” This study found that skin exposure to toluene diisocyanate in mice creates immune-recognition reservoirs in the skin's stratum corneum and hair follicles, potentially leading to sensitization and allergic reactions.
28 citations
,
November 2014 in “Current Diabetes Reports” This review discusses the complex links between polycystic ovary syndrome, insulin resistance, and potential metabolic risks starting in adolescence, noting the need for early screening and treatment but reports no new clinical results.
47 citations
,
September 1995 in “British Journal of Dermatology” This review discusses the complication of vitiligo in patients undergoing diphencyprone sensitization therapy for alopecia universalis and reports no new clinical findings.
14 citations
,
July 1987 in “Contact Dermatitis” This article lacks an abstract and presents no new findings, primarily discussing topical minoxidil sensitization in androgenic alopecia.
2 citations
,
September 2020 in “Swedish Journal of BioScience Research” This study found that chitosan from Lucilia cuprina improved burn healing in diabetic mice, promoting wound closure, epidermal remodelling, and collagen deposition, while also demonstrating antibacterial properties.
1 citations
,
September 2025 in “Physiologia” This study found that systemic ovalbumin–aluminum sensitization followed by cutaneous challenge in mice induced thermal hyperalgesia, increased spinal cord gliosis, and sprouting of nociceptive fibers, along with elevated mast cell and nerve profile densities in the skin compared to controls.
3 citations
,
January 2014 in “The Journal of Dermatology” This letter discusses a case of hapten-induced lymphadenosis benigna cutis following sensitization with squaric acid dibutylester for treating alopecia areata and reports no new clinical results.
2 citations
,
September 2020 in “International Journal of Molecular Sciences” In this study, the elimination of NG2+ hair follicle stem cells during the anagen phase was associated with an aggravated sensitization phase of allergic contact dermatitis, suggesting their immunosuppressive role.
April 2023 in “Journal of Investigative Dermatology” This study suggests that linalool, a common allergen in personal care products, may contribute to frontal fibrosing alopecia pathogenesis by triggering immune responses and depleting hair follicle stem cells, especially in sensitized individuals.
2 citations
,
March 2015 in “Toxicology and Environmental Health Sciences” This study found that rice bran supercritical CO₂ extract was classified as a non-irritant for ocular use but a moderate irritant for dermal use in rabbits and guinea pigs.
24 citations
,
February 2022 in “Journal of Biological Chemistry” This study found that carvacrol activates the TRPV3 ion channel by binding to a specific pocket formed by the S2-S3 linker, providing insight into its role in skin sensitization and potential for designing specific modulators.
January 2017 in “Nasza Dermatologia Online” This study found that both new and old formulas of DCP for treating alopecia areata resulted in similar hair regrowth, but tolerance was significantly better with DCP in isopropanol.
13 citations
,
April 2002 in “International Journal of Toxicology” This review discusses the use of human and animal-derived placental and umbilical extracts in cosmetics, highlighting insufficient data to establish their safety and recommending they should not have metabolic or endocrine activity.
11 citations
,
January 2022 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses current and emerging therapies for alopecia areata, highlights the challenges in managing this chronic disease, and emphasizes the importance of addressing its psychosocial impacts; it reports no new clinical results.
7 citations
,
April 2021 in “Journal of Bodywork and Movement Therapies” This editorial reviews the concept of central sensitization and central sensitivity syndromes, discussing their potential role linking various chronic conditions, but it reports no new clinical findings.
In this narrative hypothesis-driven overview, the authors propose reframing rosacea as a neuroimmune disorder, highlighting the interconnected role of the skin-gut-brain axis, particularly central nervous system involvement alongside gut microbiota and neurogenic inflammation, to emphasize the need for multidisciplinary therapeutic approaches.
April 2021 in “Research Square (Research Square)” This study found that the new cocrystal formulation KET-PABA improved the antimycotic efficiency of ketoconazole and induced an anti-inflammatory response without causing skin sensitization in mice.
15 citations
,
October 2021 in “Frontiers in Pharmacology” This commentary discusses the potential of natural volatiles in medical aromatherapy, highlighting their ability to synergize with other drugs and modulate biological processes, but reports no new results.
1 citations
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January 2013 in “Digital Scholarship - UNLV (University of Nevada Reno)” This study hypothesized that finasteride administration may increase stress-induced amphetamine locomotor sensitization due to its impact on brain reward systems involving the neurosteroid allopregnanolone.